Introduction: Despite the extensive use of ionizing radiation in diagnosis and therapeutic procedures, development of radio-protector agents is important in modulating normal tissue damages. Hesperidin(HES) is a Flavanone glycoside, belonging to the Flavonoid family in human diet abundantly and noted for its many beneficial effects. The aim of present study was investigated to ...

objective: in radiation treatment, the irradiation which is effective enough to control the tumors far exceeds normal-tissues tolerance. thus to avoid such unfavourable outcomes, some methods sensitizing the tumor cells to radiation are used. iododeoxyuridine (iudr) is a halogenated thymidine analogue that known to be effective as a radiosensitizer in human cancer therapy. improving the potenti...

Introduction: Radiation countermeasures are defined as use of an agent to minimize the deleterious effects of radiation therapy by administering the compound after the radiation exposure has occurred, regardless of toxicity. In spite of extensive study in this field, yet there is no suitable radioprotector introduced. In this study two naturally occurring antioxidants were stu...

introduction: different environmental factors such as drugs, ionizing radiation, etc can induce apoptosis.in the present study the effects of dose- rate and post-irradiation incubation time on gamma radiation inducedapoptosis in human breast carcinoma cell line (t-47d) (invasive ductal carcinoma) was investigated. material and methods: the t-47d cells were cultured in t25 flasks and during log ...

Large quantities of radiopharmaceuticals prescribed for treatment and diagnosis are excreted through kidney. Therefore, radiation unwanted dose is created in kidney. As a result, exact calculation of prescribed radiopharmaceuticals amount is important. Monte Carlo method is used for simulation of radiation transport in body due to random nature of radiation. In this research, for the first time...

conclusions the increasing cell toxicity, apoptosis-inducing effects and decreasing telomerase activity may play an important role in the valproic acid and radiation mechanism. the current survey suggested that it is likely beneficial to combine valproic acid and gamma radiation to treat breast cancer. results combination of valproic acid and gamma radiation increased significantly cell toxicit...

The Chinese hamster ovary cell line xrs-1 is hypersensitive to gamma-radiation. This sensitivity has been attributed to an inability of this cell line to efficiently repair gamma-ray induced double-strand breaks (DSBs). We have recently reported that xrs-1 is also sensitive to topoisomerase II inhibitors that stabilize the cleavable complex. In this study, we have investigated the basis of this...

introduction radioactive materials naturally exist in the world. indeed, approximately 82% of human-absorbed radiation doses, which are out of human control, arise from natural sources of radiation including cosmic, terrestrial, and exposure through inhalation or ingestion. thus, the aim of the present study was to estimate health risk, as well as the effective and organ doses from naturally oc...

background: since 1996 the assessment of environmental gamma radiation dose in residential areas of iranian towns and cities has been accomplished for 10 counties. as a practical method and based on the results of a pilot study, in order to attribute the final results to the whole residential area of a town five stations were selected for every town. the location of individual station was studi...