نتایج جستجو برای: gancyclovir
تعداد نتایج: 55 فیلتر نتایج به سال:
Although tissue-specific promoters offer a promising approach to the targeting of gene therapy, the activity of such promoters is generally low, which is thus a major limitation, especially when using non-viral vectors. To establish effective transcriptional targeting gene therapy for growth hormone (GH) producing pituitary tumors, an Epstein-Barr virus (EBV) based vector system expressing herp...
BACKGROUND Human Cytomegalovirus (HCMV) is the most common cause of congenital infections. The maternal immune status plays a major role in the likelihood of congenital infection. The aim of this study is to shed light on the seroprevalence of HCMV in pregnant women, hospitalized children and newborns including cases of congenital infections in Palestine. METHODS We analyzed HCMV IgG and IgM ...
Cytomegalovirus infection as a cause of cytopenia after chemotherapy for hematological malignancies.
OBJECTIVE Unlike hematopoietic stem cell transplantation, there is very little information on cytomegalovirus (CMV) related cytopenias occurring in patients having acute lymphoblastic leukemia (ALL) or Non Hodgkin’s lymphoma (NHL) receiving standard dose chemotherapy (SDCT). We studied the role of CMV infection in cytopenias after SDCT for childhood ALL or NHL. DESIGN Retrospective study. S...
BACKGROUND Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor that carries a 5-y survival rate of 5%. Attempts at eliciting a clinically relevant anti-GBM immune response in brain tumor patients have met with limited success, which is due to brain immune privilege, tumor immune evasion, and a paucity of dendritic cells (DCs) within the central nervous system. Herein we unc...
27. L. Redmond, S.-R. Oh, C. Hicks, G. Weinmaster, A. Ghosh, Nature Neurosci. 3, 30 (2000). 28. To create the CREST antibody, We used PCR to amplify full-length crest cDNA from P0 mouse brain total RNA and cloned it into pET21 vector for expression of His-tagged CREST protein in bacteria. After isopropyl-D-thiogalactopyranoside induction, CREST protein was mainly collected in the inclusion body...
Grade IV astrocytoma, termed glioblastoma multiforme (GBM) is death receptor (DR) expression on the surface of glioblastoma cells, one themost aggressive malignancies known to man. Despite intensive therapies, themedian survival has remained approximately 15months. One of themajor challenges to the treatment of CNSmalignancies is the blood brain barrier (BBB). The barrier is designed to be incr...
Discussion Efalizumab is a recombinant humanized monoclonal antibody used for chronic plaque psoriasis refractory to other systemic treatments (methotrexate, ciclosporin, PUVA therapy). The most frequent efalizumab side effects are influenza syndrome, infections, pruritus and arthritis [1–4] . Malignancies are not increased in patients treated with efalizumab [5] . A study of the clinical trial...
BACKGROUND AND OBJECTIVES Recent observations suggested that targeted monoclonal antibodies might be best employed in lymphoid malignancies under conditions of minimal residual disease. This prompted us to investigate the role of Campath-1H as treatment for patients with chronic lymphocytic leukemia (CLL) in whom fludarabine (FAMP) had produced a marked disease debulking with persistence of bon...
مقدمه: از سال 1365 لغایت 1385، به مدت 20 سال، نزدیک به 2010 مورد پیوند کلیه(عمدتاً از دهندگان غیرفامیل) در مرکز هاشمی نژاد انجام شده است. بعد از انجام عمل پیوند کلیه، به خاطر دریافت داروهای ایمونوساپرسیو، عوارضی از قبیل افزایش ریسک عفونت های باکتریال، ویرال و قارچی و همچنین بدخیمی های گوناگون، در بیماران گزارش گردیده است. با گذشت نزدیک به 20 سال از اعمال جراحی پیوند در ایران، گزارشات متعددی از م...
Partially mismatched pediatric transplants with allogeneic CD34(+) blood cells from a related donor.
This was a phase I, multi-center study of 13 pediatric patients (median age, 11 years) to evaluate toxicity, hematopoietic recovery, and graft-versus-host disease (GVHD) after allogeneic transplantation of enriched blood CD34(+) cells obtained from genotypically haploidentical but partially HLA-mismatched related donors (8 parents and 5 siblings). With regard to rejection, donor HLA disparity w...
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