A 14-year-old boy, known case of acute lymphoblastic leukemia (ALL) on maintenance treatment presented with visual loss in lower half of visual field. Laboratory tests showed pancytopenia. ALL Relapse was ruled out by bone marrow aspiration. An ophthalmologic consultation was done and a diagnosis of “CMV retinitis” was made. CMV-PCR was positive with 3,000,000 copies/ml. CTscan of chest and abd...

To report a case of cytomegalovirus (CMV) retinitis after intravitreal injection of triamcinolone acetonide (IVTA). A 77-year-old woman with macular edema due to central retinal vein occlusion (CRVO) developed peripheral retinitis 4 months after IVTA. A diagnostic anterior chamber paracentesis was performed to obtain DNA for a polymerase chain reaction (PCR) test for viral retinitis. The PCR te...

The prevalence and molecular characteristics of isolates from 173 immunocompetent patients with herpetic keratitis (HK) who were infected with acyclovir (ACV)-resistant (ACV(R)) corneal herpes simplex virus (HSV)-1 was determined. Isolates from 11 (6.4%) of the patients were ACV(R), and 9 of these 11 patients were refractory to therapy with ACV; the ACV(R) isolates from 5 and 1 of these 9 patie...

the human cytomegalovirus (cmv) is widely distributed among the human population as one of the most common causes of congenital infection with an incidence of about 0.15-2.0% in developed countries.in this case report we present a female neonate (with a maternal history of flu-like syndrome in 30 weeks of pregnancy) delivered via caesarian section with good reflexes and appropriate apgar score,...

Sir, Polyradiculopathy is a rare but potentially devastating syndrome more common in Acquired Immunodeficiency Syndrome (AIDS). Although cytomegalovirus (CMV) is most commonly implicated, the differential diagnosis includes tuberculosis, syphilis, and lymphoma. We admitted a 36-year-old army truck driver from Haryana, India, HIV-positive since May 2004, with ascending, asymmetric flaccid parapl...

Cytomegalovirus colitis is uncommon in immunocompetent hosts. Thus, a case of bloody diarrhoea and weight loss in an immunocompetent elderly man is reported. Cytomegalovirus colitis was diagnosed by identifying inclusion bodies with positive immunohistochemistry for cytomegalovirus in the histological specimens obtained by colonoscopy. The patient responded to gancyclovir treatment. We conclude...

From May 1990 to July 1994,62 patients (22 isolated intestine [I], 29 liver and intestine [IlL], and 11 multivisceral [MV]) received 66 intestinal allografts at our center. There were 28 adults and 34 children. with ages ranging from 6 months to 58 years. Postoperative immunosuppression was with tacrolimus (FK 506), steroids. and in selected cases azathioprine (AZA). Donor and recipient procedu...

Two positive and negative selectable markers were created for use in mammalian cells. They are based on two genes for the resistance to Blasticidin S (BlaS) and on the thymidine kinase (Tk) gene of herpes simplex virus (HSV). The markers can be selected positively by their ability to induce BlaS resistance and negatively on the induced sensitivity towards gancyclovir (GANC). Both constructs are...

ObjectiveMycophenolate mofetil (MMF) is commonly administered concomitantly with ganciclovir for managingtransplant recipients who infected with CMV. This study was conducted to evaluate the probable effects ofganciclovir on Mycophenolic acid (MPA) pharmacokinetic.Materials and MethodsTen kidney transplant recipients who full field inclusion and exclusion criterias enrolled in this study. Thefi...