BACKGROUND Gastroesophageal reflux is associated with numerous pathologic conditions of the upper aerodigestive tract. Gastric pepsin within reflux contributes to immunologic reactions in the tonsil. In this study, we aimed to find the relationships between pepsin and tonsillar hypertrophy. METHODS AND FINDING We explored the notion whether tonsillar hypertrophy was due to pepsin-mediated gas...

1. Alkali (pH 7.6)-denatured pepsins from swine, cattle, and guinea pigs precipitate in swine pepsin antiserum. Similarly treated pepsins from the rabbit, chicken, and shark do not. 2. Pepsin antisera react with both pepsin and pepsinogen, but do not react with the serum proteins from the homologous species. 3. Pepsinogen antisera react with pepsinogen, but not with twice crystallized pepsin, n...

Objective(s) The liver has major role in the organism homeostasis, interactions with other systems, synthesis and metabolism of bile production, drug detoxification and hormone inactivation. Cholestasis can be defined as an impairment of the bile flow which can lead to hepatocytes necrosis and finally cirrhosis. Some studies reported a gastric acid secretion reduction in cirrhotic subjects, wh...

Background and Objective: Antimicrobial peptides have attracted significant attention in recent decades because of their properties, such as rapid bactericidal effects, having a wide spectrum of activity, and a rare development of drug resistance. The purpose of this study was to examine the antibacterial activity of a peptide derived from the lactoferrin isolated from camel milk against Staphy...

Background/Aims Increased salivary pepsin could indicate an increase in gastro-esophageal reflux, however, previous studies failed to demonstrate a correlation between salivary pepsin concentrations and 24-hour esophageal acid exposure. This study aims to detect the salivary pepsin and to evaluate the relationship between salivary pepsin concentrations and intercellular spaces (IS) in different...

The pepsin used in the preliminary experiments of this study was prepared from Parke, Davis pepsin by the method of Philpot (2) and was twice recrystallized. It was stored until used under half saturated magnesium sulfate solution at 2”. Pepsin A was prepared from Cudahy pepsin by the fractionation procedure of Herriott, Desreux, and Northrop (3). Its solubility in 0.05 M acetate, pH 4.6, 0.5 s...

OBJECTIVES At the cellular level, tissue-bound pepsin is fundamental to the pathophysiologic mechanism of reflux disease, and although the thresholds for laryngeal damage in laryngopharyngeal reflux and for esophageal damage in gastroesophageal reflux disease differ, both forms of damage are due to pepsin, which requires acid for its activation. In addition, human pepsin remains stable at pH 7....

The conversion of pepsinogen to pepsin has been followed by means of the fluorescent probe, Z-p-toluidinonaphthalene6-sulfonate (TNS). It was found that the change in fluorescence accurately reflects the formation of active pepsin. The data on the binding of TNS to pepsinogen and pepsin suggest that the environment surrounding the fluorophore is altered during the conversion. One of the peptide...