The control of intestinal α-amylase and α-glucosidase is an effective therapeutic strategy for prevention post-prandial hyperglycemia associated with diabetes mellitus. objective this study was to evaluate the anti-diabetes activities Korean edible seaweed against α-glucosidase, two carbolytic enzymes involved in serum glucose regulation. Of 41 species initially screened, Cladophora wrightiana ...

The aim of the present study was to synthesize isoflavone-enaminones 3a-c and 7-alkoxy-isoflavones 4a-c, evaluate their inhibition ?-glucosidase, analyze bioisosteric effect presence versus absence aromatic moieties in these benzopyran derivatives. All test compounds exhibited greater ?-glucosidase than positive control acarbose. series isoflavones 4a-c showed higher inhibitory activity (IC50 =...

Objective: Alpha-glucosidase, as a carbohydratase catalyses the liberation of alpha-glucose from the nonreducing end of some carbohydrates from foods in digestive tract.  Consequently, retard absorption of glucose by the inhibition of carbohydrate hydrolyzing enzymes is one of the therapeutic approaches to decrease the postprandial hyperglycemia. Recently, a great deal of attention has been pai...

The objective of the present study was to evaluate the inhibitory properties of various extracts of propolis on alpha-glucosidase from baker's yeast and mammalian intestine. Inhibitory activities of aqueous ethanol extracts of propolis were determined by using 4-nitrophenyl-D-glucopyranoside, sucrose and maltose as substrates, and acarbose as a positive reference. All extracts were significantl...

Anti-diabetic capacity of Curcuma longa volatile oil in terms of its ability to inhibit glucosidase activities was evaluated. Turmeric volatile oils inhibited glucosidase enzymes more effectively than the reference standard drug acarbose. Drying of rhizomes was found to enhance α-glucosidase (IC₅₀ = 1.32-0.38 μg/ml) and α-amylase (IC₅₀ = 64.7-34.3 μg/ml) inhibitory capacities of volatile oils. ...

Inhibition of intestinal alpha glucosidase plays a major role in preventing rise in postprandial glucose level in diabetics. Cymbopogon martinii (CM) (family Poaceae) is used in traditional Indian medicine in treatment of diabetes mellitus. The alpha glucosidase inhibitory action of the plant is studied. The active component was separated using hot water extraction of the whole plant powder, di...

The side effects associated with the usage of synthetic antidiabetic drugs make it imperative to search for alternative drugs from medicinal plants. Therefore, this study was aimed at evaluating the α-amylase and α-glucosidase inhibitory potential of Calotropis procera leaf, as well as its possible mode of inhibiting these enzymes. Acetone, aqueous and ethanolic extracts of C. procera leaf was ...

Continuing our interest in the Uncaria genus, the phytochemistry and the in-vitro α-glucosidase inhibitory activities of Malaysian Uncaria cordata var. ferruginea were investigated. The phytochemical study of this plant, which employed various chromatographic techniques including recycling preparative HPLC, led to the isolation of ten compounds with diverse structures comprising three phenolic ...

The nano sized copper oxide material (CuONPs) were prepared by the greener way and an approach functionalized polymer using Sarcostemma acidum stem extracts. in-vitro anti-diabetic activity was studied through α-glucosidase α-amylase inhibitory methods demonstrated in stem, biological synthesized CuONPs polymerized CuONPs. percentage inhibition at 100 μg/ml, 200 300 400 μg/ml 500μg/ml concentra...