Acute allograft pancreatitis is common following simultaneous pancreas and kidney (SPK) transplantation with either bladder or enteric drainage w1,2x. Allograft pancreatitis may be caused by infection, bladder drainage problems, alcohol, drugs and diet w1x. Pancreatic allograft rejection, usually occurring in the context of renal allograft rejection, may cause a syndrome similar to acute allogr...

Kidney transplantation is a method of choice as a treatment for end-stage renal disease in indicated cases. However, the long graft survival represents only about 50% due to various types of rejection as a leading cause of graft loss in renal transplant recipients. The early dg. of rejection and especially acute rejection, it's adequate management, decreased risk for the future chronic rejectio...

BACKGROUND AND AIM The most common complication of renal transplantation is allograft dysfunction, which in some cases leads to graft loss. The role of graft nephrectomy in the management of transplant failure is controversial. The procedure remains associated with a significant morbidity and also mortality. Our main purpose was the comparison between clinical and pathological diagnosis of graf...

Ever since the inception of kidney transplant programs the short-term patient and graft survival results have improved progressively, principally because of better management of acute rejection episodes and decreased mortality from infectious complications. However, the rate of annual graft attrition after the first post-transplant year has virtually remained unchanged [1, 2]. About half to thr...

background: thymoglobuline (tg), is used for both induction and rejection therapy in kidney transplantation (tx). this study was conducted to compare between adding tg or not to the conventional drugs to evaluate the rate of rejections, infections and costs. methods: in two groups of patients, each of 45 cases group a received conventional drugs (cyclosporine, mycophenolate and prednisolone) an...

INTRODUCTION Graft monitoring following vascularized composite allotransplantation (VCA) relies primarily on serial skin biopsy. However, given that VCA comprised multiple tissue types, skin biopsy may not accurately reflect rejection in other transplanted tissue. METHODS A review of the literature on episodes of both acute and chronic rejection following VCA was completed. Special attention ...

Graft rejection remains a significant concern after hematopoietic stem, cell transplantation (HSCT). While its incidence and predisposing factors are well known in the setting of solid organ transplantation (SOT), the study of graft rejection still remains an area of active investigation in case of HSCT. Recipient T cells, natural killer cells and antibodies are implicated in graft rejection. O...

Peritubular capillary deposition of C4d has been demonstrated to be associated with both acute humoral and vascular rejection and increased graft loss. Whether it is an independent predictor of long-term graft survival rates is uncertain. The biopsies (n = 126) from all patients (n = 93) with a tissue diagnosis of acute rejection that were performed between July 1, 1995, and December 31, 1997, ...

BACKGROUND Interleukin-10 (IL-10) is an important immunomodulatory cytokine. Several studies focused the association between IL-10 promoter gene polymorphisms and graft rejection risk in kidney transplantation recipients. However, the results of these studies remain inconclusive. The aim of this study was to conduct a meta-analysis to further assess the associations. METHODS The PubMed, Embas...

Successful engraftment of organ transplants has traditionally relied on preventing the activation of recipient (host) T cells. Once T-cell activation has occurred, however, stalling the rejection process becomes increasingly difficult, leading to graft failure. Here we demonstrate that graft-infiltrating, recipient (host) dendritic cells (DCs) play a key role in driving the rejection of transpl...