The influenza A (H1N1) virus causes seasonal epidemics that result in severe illnesses and deaths almost every year. A deep understanding of the antigenic patterns and evolution of human influenza A (H1N1) virus is extremely important for its effective surveillance and prevention. Through development of antigenicity inference method for human influenza A (H1N1), named PREDAC-H1, we systematical...

We previously developed a rapid and simple gold nanoparticle(NP)-based genomic microarray assay for identification of the avian H5N1 virus and its discrimination from other influenza A virus strains (H1N1, H3N2). In this study, we expanded the platform to detect the 2009 swine-origin influenza A virus (H1N1/2009). Multiple specific capture and intermediate oligonucleotides were designed for the...

• In influenza-immune subjects, H1N1 influenza virus–containing immune complexes can activate platelets through FcgRIIA. • H1N1 can also activate platelets through thrombin, independently of FcgRIIA, pointing to a role of coagulation in influenza infection. Platelets play crucial functions in hemostasis and the prevention of bleeding. During H1N1 influenza A virus infection, platelets display a...

BACKGROUND: Pandemic 2009 H1N1 influenza A virus arrived at Isfahan in August 2009. The virus is still circulating in the world. The abnormal thoracic computerized tomographic (CT) scan findings vary widely among the studies of 2009 H1N1 influenza. We evaluated the thoracic CT findings in patients with 2009 H1N1 virus infection to describe findings compared to previously reported findings, and ...

respiratory failure is a serious complication of h1n1 influenza that, if not properly managed, can cause death. when mechanical ventilation is not effective, the only way to save the patient’s life is extracorporeal membrane oxygenation (ecmo). a prolonged type of cardiopulmonary bypass, ecmo is a high-cost management modality compared to other conventional types and its maintenance requires sk...

BACKGROUND This study was conducted from 2006 to 2010 and investigated the seroprevalence of influenza A viruses in Cambodian pigs, including human H1N1, H3N2, 2009 pandemic H1N1 (A(H1N1)pdm09), and highly pathogenic avian H5N1 influenza A viruses. METHODS A total of 1147 sera obtained from pigs in Cambodia were tested by haemagglutination inhibition (HI) assays for antibody to human influenz...

Purpose. To provide an overview of the 2009 H1N1 influenza pandemic and antiviral treatment options for influenza. Summary. Influenza infection causes significant morbidity and mortality every year. The high mutation rate and segmented nature of influenza virus genome gives rise to high genetic variability which enables the virus to escape antiviral and vaccine interventions. A novel H1N1 strai...

CDC first identified cases of respiratory infection with a novel influenza A (H1N1) virus in the United States on April 15 and 17, 2009. During seasonal influenza epidemics and previous pandemics, pregnant women have been at increased risk for complications related to influenza infection. In addition, maternal influenza virus infection and accompanying hyperthermia place fetuses at risk for com...

BACKGROUND The human B-cell response to natural influenza virus infection has not been extensively investigated at the polyclonal level. METHODS The overall B-cell response of patients acutely infected with the 2009 pandemic influenza A(H1N1)pdm09 virus (A[H1N1]pdm09) was analyzed by determining the reactivity of plasmablast-derived polyclonal antibodies (PPAbs) to influenza proteins. Recipie...

MicroRNAs have been implicated in the regulation of gene expression of various biological processes in a post-transcriptional manner under physiological and pathological conditions including host responses to viral infections. The 2009 pandemic H1N1 influenza virus is an emerging reassortant strain of swine, human and bird influenza virus that can cause mild to severe illness and even death. To...