chronic anemia is common in liver cirrhosis. in this setting the pathogenesis of anemia is complex and multifactorial. spur cell anemia is a serious disorder in cirrhotic patients associated with poor prognosis. liver transplantation constitutes the only therapeutic tool. we report a case of  a severe spur cell anemia in alcoholic liver cirrhosis. in the attempt to investigate the origin of the...

INTRODUCTION Haemolysis of blood samples is a common problem encountered in the Emergency department (ED). It leads to inaccurate blood results and has cost implications as blood samples very often have to be retaken. The purpose of our study was to determine which factors in blood sampling were associated with higher rates of haemolysis. MATERIALS AND METHODS An observational convenience sam...

Gamma-irradiation of blood components is regarded a safe procedure used for prevention of transfusion associated graft-versus-host disease. However, reports showed that irradiation can cause erythrocyte haemolysis and damage to the RBC membrane. In University Kebangsaan Malaysia Medical Centre (UKMMC), a number of suspected transfusion reactions (TR) featured unusual isolated episodes of red-co...

The aim of our experiments was to characterise and to validate the osmotic fragility test when applied to human blood samples with no significant alterations of osmotic fragility but with a differentiating shape of the haemolysis curve. All experiments were carried out on human erythrocytes taken from the Regional Centre of Blood Donation and Blood Therapy in Wrocław. The washed erythrocytes we...

BACKGROUND Drug-induced immune haemolytic anaemia (DIHA) is difficult to diagnose, and its true incidence remains obscure. Here, we present cases of DIHA identified at our institute over the last two decades. METHODS Serological tests were performed according to standard procedures. Detection of drug-dependent antibodies was performed in the presence and absence of the relevant drug and/or th...

Haemolysis in cardiac surgery is a common intractable problem, the consequences of which are still undervalued. Every study on this topic has attracted considerable interest, and the paper of Ricci et al. cannot be overlooked [1]. There are two main causes of haemolysis during cardiac surgery: effect of extracorporeal circulation support devices on patient’s blood (cardiopulmonary bypass, extra...

In studying the pathogenesis of anaemia associated with many clinical disorders one is often confronted with the problem of whether intravascular haemolysis is taking place. Haemolysis may result either from an intrinsic abnormality of the red cell, rendering it of shorter life span than normal, and this may be of an hereditary or acquired nature, or, alternatively, from the presence of some pl...