I N AN EARLIER report,' Schwartz and co-workers presented evidence which suggested that the genes controlling the formation of hemoglobins S and GG an Jose are nonallelic. Recent studies2 have shown that these hemo-globins differ from hemoglobin A as follows: Each sequence represents the first eight amino acids from the amino terminus of the $-chains. In view of recent suggestions on the nomenc...

CLINICAL MANIFESTATIONS OF INHERITED ABNORMAL HEMOGLOBINS. I. THE / \. INTERACTION OF HEMOGLOBIN-S WITH HEMOGLOBIN-D. II. INTERACTION / OF HEMOGLOBIN-E AND THALASSEMIA TRAIT Phillip Sturgeon, Harvey A. Itano and William R. Bergren 389 STUDIES ON ABNORMAL HEMOGLOBINS. XI. SICKLE CELL-THALASSEMIA DISEASE IN THE NEGRO. THE SIGNIFICANCE OF THE S + A + F AND S -4A PATTERNS OBTAINED BY HEMOGLOBIN ANA...

background: hydrogen sulfide (h 2 s) exhibits both physiological and toxicological roles in the biological systems. acute exposure to high levels of h 2 s is life threatening while long-term exposure to ambient levels of h 2 s elicits human health effects. objective: to study the harmful effects of long-term exposure to low levels of h 2 s on human blood cells. methods: 110 adult workers from i...

The oxidation-reduction equilibrium of human hemoglobin treated with various sulfhydryl reagents has been studied. The following modified hemoglobins have been characterized: hemoglobin treated with cystine, hemoglobin treated w2th cystamine, hemoglobin treated with iodoacetamide, and hemoglobin treated with 2 eq of p-mercuribenzoate. In all cases the modified hemoglobins have an oxidationreduc...

Hemoglobins are recognized today as a diverse family of proteins present in all kingdoms of life and performing multiple reactions beyond O2 chemistry. The physiological roles of most hemoglobins remain elusive. Here, we show that a 2-on-2 ("truncated") hemoglobin, termed THB8, is required for hypoxic growth and the expression of anaerobic genes in Chlamydomonas reinhardtii. THB8 is 1 of 12 2-o...

Giant extracellular hemoglobins, also known as erythrocruorins, have been investigated as a model of extreme complexity in oxygen-binding heme proteins [1,2]. They are characterized by a very high molecular mass (MM) of several megadalton (MDa), and their oligomeric structure together with the crowded and protected heme environment are two of the main factors responsible for the high redox stab...

Hbs are ubiquitous proteins in most organisms, including bacteria, protozoans, fungi, plants, and animals (Vinogradov et al., 1993; Bolognesi et al., 1997). The known and predicted roles of Hbs in each organism encompass functions that include the reversible binding of gaseous ligands and the ability to bind other cellular molecules. Link to full text: http://www.plantphysiol.org/cgi/content/fu...