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BACKGROUND Platelet aggregation plays an important role in arterial thrombosis in coronary heart disease, stroke, and peripheral arterial disease. However, the contribution of genetic versus environmental influences on interindividual variation in platelet aggregability is poorly characterized. METHODS AND RESULTS We studied the heritability of platelet aggregation responses in 2413 participa...

SOURCE/DESCRIPTION: A 2184 bp cDNA (H.4 IRBP) encoding human interstitial retinol-binding protein (IRBP; Fong et al., 1984) isolated from a human retina cDNA library in XgtlO by screening with a bovine IRBP cDNA probe (B.23; Liou et al., 1986). POLYMORPHISM: Bgl II (AGATCT) identifies a 2-allele polymorphism with bands at 6.3 kb (A1) and 4.3 kb (A2). There is a strong invariant band at 2.5 kb. ...

Sites for restriction endonuclease cleavage in double helical DNA are blocked from cleavage when the photoaffinity drug trimethylpsoralen is photobound at or near the site. In general, Hind III sites are about 15 fold more sensitive to inactivation than the other restriction sites which were tested, although sensitivity of different Hind III sites seems to vary somewhat depending on base sequen...

AMA AboShabaan H, Alghannam O, Ismail F, et al. Bone morphogenic protein-7 (BMP-7) polymorphism: Susceptibility to cirrhosis and hepatocellular carcinoma after viral hepatitis in Egyptian patients. Clinical Experimental Hepatology. 2023;9(2):164-171. doi:10.5114/ceh.2023.128616. APA AboShabaan, H., Alghannam, O., Ismail, F., El-Garawani, I., El-Shahat, M., & Talaat, R. (2023). Hepatology, 9(2),...

Molecular phylogeny and genetic diversity in all the nine species (Rhizophora mucronata, R. apiculata, R. stylosa, Bruguira cylindrical, B. parviflora, B. gymnorriza, Ceriops tagal and C. decandra) and a natural Rhizophora hybrid, of the mangrove Rhizophoraceae, occurring in the Indian sub-continent were analysed using random amplified polymorphic DNA (RAPD), restriction fragment length polymor...

Highly repetitive Hind III restriction fragments of 0.72-0.76 KBP from total Xenopus laevis genomic DNA are organized in a tandem like arrangement. Cloning of these fragments in pBR 322 with subsequent restriction site mapping and nucleotide sequence analysis of some selected clones showed two different types of sequences. 25-30% of material represent the oocyte specific 5 S DNA repeat units, 7...

An attempt has been made to analyze the distribution of the beta-lactoglobulin genotype in swamp buffaloes and Murrah buffaloes utilizing polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). Blood samples were taken from 50 swamp buffaloes and 50 Murrah buffaloes. The DNA was extracted by the phenol-chloroform method. The PCR-RFLP was performed using beta-lactoglobulin ...