Background & Aims: Lipoprotein lipase (LPL) is one of the key enzymes regulating the metabolism of triglycerides (TG) and HDL cholesterol. The lipoprotein lipase (LPL) gene polymorphisms are possibly involved in the pathophysiology of dyslipidemia. Hind III polymorphism is one of the most common polymorphisms in LPL gene. In some studies, association of Hind III polymorphism with dyslipidemia h...

Background: Coronary artery disease (CAD) is one of the leading causes of death and disability around the world. Interaction between genetic and environmental factors determines susceptibility of an individual to develop coronary artery disease . Lipoprotein lipase (LPL) play an important role in the metabolism of HDL-C ( High Density Lipoprotein Cholesterol ), LDL-C (Low Density Lipoprotein Ch...

background: coronary artery disease (cad) is one of the leading causes of death and disability around the world. interaction between genetic and environmental factors determines susceptibility of an individual to develop coronary artery disease . lipoprotein lipase (lpl) play an important role in the metabolism of hdl-c ( high density lipoprotein cholesterol ), ldl-c (low density lipoprotein ch...

OBJECTIVE To investigate the relevance between lipoprotein lipase (LPL) Hind III gene polymorphism and cerebral hemorrhage. METHODS A case-control study was performed utilizing PCR-RFLP method and sequencing of amplified products to detect LPL Hind III gene polymorphism in 350 cases of hemorrhagic stroke (HS group) and 350 healthy subjects (control group). Blood lipids and glucose levels were...

This study was performed to assess the effect of the S447X and Hind III lipoprotein lipase gene polymorphisms on development of coronary artery disease and hypertriglyceridemia. The study included 132 patients and 98 healthy control subjects of Croatian descent. The lipoprotein lipase S447X polymorphism was associated with coronary artery disease and hypertriglyceridemia, as indicated by the lo...

Restriction fragment length polymorphism of the rat albumin gene was discovered in a stock of Sprague-Dawley rats by Southern blots of rat liver DNAs using cloned albumin cDNA, prAlb-1 (1), as a probe. The polymorphic DNA fragments were observed when rat DNAs were digested with either Hind III or Pst 1 and the difference in length of the DNA fragments in Hind III or Pst 1 digests was estimated ...

SOURCE/DESCRIPTION: An anonymous 1.3kb Hind III/EcoRI fragment in pUC19, subcloned from a 7.5kb Xbal/EcoRI genomic clone. The fragment is coamplified with c-Ki-ras 2 in DNA from a metastatic human lung carcinoma (Heighway and Hasleton, 1986). POLYMORPHISM: Stu 1 identifies a simple two allele polymorphism with bands at either 2.5 or 8.7kb. FREQUENCY: Studied in 35 unrelated Caucasians 2.5 kb al...

SOURCE AND DESCRIPTION OF CLONE: pi,2-2, a 1.8 Kb EcoRI fragment was subcloned in pBR322, derived from a genomic library in Charon 21A which was constructed from sorted by flow cytometry human chromosome 1 and 2. POLYMORPHISM: EcoRI indentifies two alleles with DNA fragments at either 1.8 Kb (Al) or 1.0 and 0.3 Kb (A2), Hind III identifies two alleles with DMA fragments at either 5.0 (Bl) or 8....

OBJECTIVE To investigate the relationship between lipoprotein lipase (LPL) gene polymorphism and cerebral hemorrhage in a Chinese population. METHOD This study was based on the case-control study, PCR-RELP and sequencing method were utilized for genotyping. LPL gene Hind III polymorphism was detected both in 300 patients with cerebral hemorrhage (CH group) and in 300 healthy control subjects ...

SOURCE AND DESCRIPTION OF CLONE: A 973 bp cDNA insert from an adult human kidney library cloned in the EcoRI site of PBR 327 (pINSR 18.2) encoding aminoacids-26 to 295 of the insulin receptor. POLYMORPHISM EcoRI identifies a two allele polymorphism with bands at 22 fcb and 20 Kb Hind III detects two allelic fragments of 6.5 Kb and 1.4 kb Pst I reveals two allelic fragments of 2.