1Department of Pharmaceutics, SriVenkateshwara College of Pharmacy and Research center, Affiliated to Osmania University, Madhapur, Hitech City, Hyderabad500081,Andhra Pradesh, India. A b s t r a c t Sitagliptin phosphate when used alone is an oral anti hyperglycemic drug of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. It is available as tablets under trade name JANUVIA. Metformin hydroc...

Objective: The major objective of this study was to prepare and evaluate OnceDaily Sustained Release Matrix Pellets Formulation of Aceclofenac by using Extrusion-Spheronization technique. Methods: The sustained release matrix pellets of Aceclofenac were prepared by industrially applied extrusion spheronization technique. The different formulations were prepared using HPMC K100M LVCR as hydrophi...

The present investigation reports the design and evaluation of six-hour extended release film-coated matrix tablets of cephalexin using different grades of hydrophilic polymer hydroxypropylmethylcellulose (HPMC) employing direct compression method. The preformulation studies performed included the physical compatibility studies, Differential Scanning Calorimetry analysis, drug characterization ...

Objective: The Losartan potassium mucoadhesive buccal tablet were prepared using mucoadhesive polymers such as Carbopol 940P, pectin, sodium CMC, Sodium alginate, HPMC K4M, HPMC K15M and HPMC K100M in alone and in combination as release retarding agent to prolong the drug release and to avoid first pass metabolism. Methods: The mucoadhesive buccal tablets were prepared by direct compression met...

Hydrophilic matrices are of utmost interest for oral prolonged release drugs. However, they show decreasing rate over time, mainly due to lengthening the diffusional pathway across gel formed upon glass-rubber transition polymer. Therefore, achievement zero-order kinetics, which could reflect in constant drug plasma levels, is still an open issue. With aim improving performance hydroxypropyl me...

The use of hydrophilic polymers from natural origin. Especially the polysaccharides have been focus current research activity in design matrix device due to their non toxic, biocompatible, biodegradable nature and broad regulatory acceptance. A large number such as Carboxymethyl starch, Xanthan gum, Hydroxy propyl methyl cellulose (HPMC), Sodium Alginate etc, used matrices investigate release b...

Nizatidine is a gastroprotective drug with short biological half-life and narrow absorption window. This study aimed at developing floating tablets of nizatidine using various HPMC viscosity grades, namely K4M, E4M, K15 K200M. Directly compressed revealed an excellent uniformity in hardness, thickness weight was evenly distributed within the matrix tablets. Buoyancy lag time as low 18–38 s, rem...

Acyclovir (ACV), a model drug for this study, is one of the most effective drugs against viruses of the herpes group. Absorption of orally administered ACV is variable and incomplete, with a bioavailability of ca. 15-30%. The drug is absorbed in the duodenum after oral administration and hence, preparation of a floating drug delivery system (FDDS) for ACV may increase oral absorption of the dru...

The present investigation studies the effect of water swellable polymer hydroxylpropylmethyl cellulose (HPMC K4M, Methocel) on in vitro release of ondansetron from suppositories. Suppositories were prepared by using mixture of Poloxamer 407 and Poloxamer 188 hydrophilic bases. Suppositories containing 16 mg of ondansetron were prepared by fusion method. Weight variation, content uniformity, bre...