It is generally accepted that acromegaly is often associated with hypercalciuria, but there are few reports on the frequency and the mechanisms of urolithiasis. Recently we consecutively experienced 2 cases of acromegaly with urolithiasis, and these experiences made us investigate the association between urolithiasis and acromegaly. Among 18 acromegalies from 1977 to March 1990 (10 males, 8 fem...

Nephrolithiasis, with a lifetime incidence of up to 13% (1–9), results in significant morbidity as well as substantial economic costs, not only directly from medical treatment but also indirectly through time lost from work. Approximately 70% of kidney stones are composed of calcium, generally combined with oxalate and/or phosphate (1,7). Hypercalciuria is the most consistent metabolic abnormal...

background: previous studies have demonstrated that patients with insulin-dependent diabetes mellitus (iddm) have a high prevalence of osteopenia.  hypercalciuria has also been well documented in human diabetes and many children with insulin-dependent diabetes mellitus have short stature.   objective: to investigate the relationship of hypercalciuria and hyperphosphaturia with growth retardatio...

UNLABELLED Dent disease is a rare X-linked tubulopathy with low molecular weight proteinuria, hypercalciuria, nephrolithiasis, nephrocalcinosis and progressive renal failure. We describe the case of a 9-year-old boy who presented with nephrotic-range albuminuria at the age of 3 years. In the absence of a clear diagnosis, a renal biopsy was performed at 4 years, which revealed minimal change dis...

Renal idiopathic stone disease affects about 8% of the Italian population. The most common form in western countries (70- 80% of the cases) is calcium nephrolithiasis, with stones formed mainly by calcium oxalate and phosphate. One of the main metabolic anomalies that is often associated with calcium nephrolithiasis is hypercalciuria. Primary hypercalciuria is a metabolic defect characterized b...

patients and methods this study was a randomized double-blind placebo-controlled clinical trial. a hundred boys with pmne and ihc were randomly assigned into two groups of experimental (treated with hct 1 mg/kg/day) and control and all patients were followed for 4 months for the number of wet-night episodes. results the mean numbers of wet-night episodes in the first (intervention: 8.34 ± 8.54,...

background wilson’s disease (wd) is a rare autosomal-recessive disorder characterized by a mutation in the atp7b gene, located on chromosome 13, which encodes a protein involved in the metabolism of copper. case presentation we described the case of an indian male with a history of polydipsia and polyuria, related to hypercalciuria and consequent nephrocalcinosis. the symptoms began at the age ...