Clindamycin is one of the important alternative antibiotics in the therapy of Staphylococcus aureus infections. Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that confer resistance to macrolides, lincosamides and Streptogramin B (MLSB) antibiotics. In vitro routine tests for clindamycin susceptibility may fail to detect inducible clindamycin resistance due...

INTRODUCTION Clindamycin is an alternative antibiotic in the treatment of Staphylococcus aureus (S.aureus) infections, both in infections by methicillin susceptible and resistant (MSSA and MRSA) strains. The major problem of use of clindamycin for staphylococcal infections is the presence of inducible clindamycin resistance that can lead to treatment failure in such infections. AIM To determi...

Mutations in the erm(41) gene of M.abscessus group organisms are associated with differences in inducible macrolide resistance, with current recommendations being to hold rapidly growing isolates for up to 14 days in order to ensure that resistance which develops more slowly can be detected. This study aimed to determine the ideal incubation time for accurate identification of inducible macroli...

BACKGROUND Virginiamycin use in poultry selects for Enterococcus faecium with cross-resistance to quinupristin-dalfopristin, a drug for vancomycin-resistant E. faecium in humans. We conducted an epidemiologic study of poultry exposures as risk factors for human carriage of quinupristin-dalfopristin-resistant E. faecium. METHODS Rectal or fecal samples for E. faecium testing were obtained from...

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infection occurs commonly in children. Clindamycin resistance may be inducible or constitutive, and the rates of inducible resistance in CA-MRSA that could produce clindamycin treatment failures vary worldwide. The double-disk test was performed in 197 erythromycin-resistant and clindamycin-susceptible CA-MRSA strains from...

Induced clindamycin resistance poses a major problem for the use of this drug to treat staphylococcal infections. An infectious etiology is often implicated in presence CoNS clinical specimens. A total 183 isolates Staphylococci spp. recovered from different specimens were studied. coagulase test was done select negative Staphylococci, and they confirmed by conventional microbiological techniqu...

9 Clindamycin is increasingly used to treat canine pyoderma. Eight of 608 Staphylococcus 10 pseudintermedius isolates were positive for inducible clindamycin resistance by D-test and PCR 11 detection of ermB. Staphylococcus pseudintermedius isolates that are erythromycin-resistant but 12 clindamycin-susceptible by in vitro antimicrobial susceptibility testing should be tested for 13 inducible c...