Transcription factors of the interferon regulatory factor (IRF) family have a critical role in the activation of interferon (IFN) genes. All cellular IRFs share a region of homology in the amino terminus encompassing a highly conserved DNA binding motif characterized by five tryptophan repeats, but show variability in the carboxy (C-) terminal part of the IRF polypeptides. While some of these I...

Introduction: The Phase III IMbrave150 study established atezolizumab + bevacizumab as standard of care in patients with unresectable hepatocellular carcinoma (HCC). This exploratory analysis reports efficacy and safety results baseline Barcelona Clinic Liver Cancer (BCLC) Stage B disease. Methods: Patients systemic treatment-naive HCC Child-Pugh Class A liver function were randomized 2:1 to re...

BACKGROUND Idiopathic retroperitoneal fibrosis (IRF) as an uncommon cause of obstructive uropathy is often primarily treated medically by the attending urologist. We evaluated dynamic enhancement analysis (DEA) as a possible predictor of response to medical treatment and for treatment monitoring. METHODS From 2007, 24 patients with fibrosis were assessed by magnetic resonance imaging (MRI) wi...

the higher national council of medical sciences planning (hncmsp) in iran compile and approve educational programs by using expert academic staff, considering the country , s needs and studying the background of establishment of each major in other countries. since the employment of graduates in occupations related to their majors is of utmost importance in educational planning, this survey has...

IFN regulatory factor (IRF)-2(-/-) mice are significantly more resistant to LPS challenge than wild-type littermates, and this was correlated with increased numbers of apoptotic Kupffer cells. To assess the generality of this observation, and to understand the role of IRF-2 in apoptosis, responses of peritoneal macrophages from IRF-2(+/+) and IRF-2(-/-) mice to apoptotic stimuli, including the ...

ABSTRACT A 13-year-old boy known for steroid-resistant nephrotic syndrome taking cyclosporine the last four years was referred from one private hospital non-response to treatment and decreased hearing. On detailed history, it revealed that hearing loss started after initiation of with during first year, patient not properly followed issues. Rather continued despite no response treatment. The ra...

Genomics has revolutionized biology, enabling the interrogation of whole transcriptomes, genome-wide binding sites for proteins, and many other molecular processes. However, individual genomic assays measure elements that interact in vivo as components of larger molecular machines. Understanding how these high-order interactions drive gene expression presents a substantial statistical challenge...

Activation of pattern recognition receptors and proper regulation of downstream signaling are crucial for host innate immune response. Upon infection, the NF-κB and interferon regulatory factors (IRF) are often simultaneously activated to defeat invading pathogens. Mechanisms concerning differential activation of NF-κB and IRF are not well understood. Here we report that a MAVS variant inhibits...