OBJECTIVE To compare the effectiveness of intermittent with daily chemotherapy (both containing rifampicin) in childhood tuberculosis (age 16yrs) in achieving cure significant improvement. DESIGN Systematic Review and Meta-analysis. METHODS MEDLINE and the Cochrane Library were searched for randomized trials of antitubercular regimens containing rifampicin, in children 16 yrs or less with t...

The natural killer (NK) activity against K 562 target cells was explored in 20 children with acute lymphoblastic leukemia (ALL). Three of 5 patients examined at the time of diagnosis had normal NK activity. Two patients, who had more than 80% circulating blasts had significantly low NK activity. The level of NK activity of these 5 patients was inversely proportional to the percentage of blast c...

a 33-year-old female presented with intermittent abdominal pain and severe attacks of lower gastrointestinal (gi) bleeding since 2 weeks. she has had history of irregular menses in last 3 months. in the labeled rbc-scan study, the bleeding site was detected in left upper quadrant (luq). in surgery, a tumor with the diameter of 2ã—1cm in a 65 cm distance of ligament of trietz was detected. in pa...

BACKGROUND An important goal of intermittent strategies of delivering systemic treatment as first-line treatment of metastatic colorectal cancer (mCRC) is to maintain efficacy while improving patients' quality of life (QoL). Given the varying impact on efficacy demonstrated in individual randomized, controlled trials (RCTs), a systematic review and meta-analysis of RCTs of these intermittent st...

In metastatic disease adjuvant androgen deprivation ADT Monotherapy is the treatment of choice. These are patients who can­ not be cured and some data suggest that intermittent hormone therapy can lead to a better life quality than a continuous one. The substantial reduction in pain and therapy related morbidity often makes chemotherapy with Docetaxel for hormone refrac­ tive prostatic cancer a...

purpose : to evaluate the role of orthoptic treatments in the management of intermittent exotropia methods : in a retrospective study, clinical records of patients diagnosed with intermittent exotropia were reviewed. patients with basic, convergence insufficiency (ci) and divergence excess (de) types of intermittent exotropia who underwent orthoptic treatments were enrolled. office treatments i...

A 12-year-old boy presented with primary Ewing's sarcoma of the occipital bone manifesting as intermittent high fever and local pain in the occipital region. Plain skull x-ray films disclosed an unclear lytic lesion in the occipital bone. Computed tomography and magnetic resonance imaging demonstrated the irregularly enhanced mass. The tumor was removed totally. He received intensive chemothera...

The drug-parasite relationships for isoniazid and rifampicin have been investigated, using cultures of M. tuberculosis and infected guinea-pigs. It is remarkable that there appear to be two entirely different mechanisms involved in intermittent chemotherapy with isoniazid and rifampicin. With isoniazid, any escape from the influence of the drug leads to diminished efficacy. On the other hand, w...