Mucosal retinoic receptor-related orphan receptor (ROR)γt-expressing innate lymphoid cells (ILC) play an important role in the defense against intestinal pathogens and in promoting epithelial homeostasis and adaptation, thereby effectively protecting the vertebrate host against intestinal inflammatory disorders. The functional activity of RORγt(+) ILC is under the control of environmental cues....

Abstract Gastrointestinal mucosa forms a surface that interacts with many external factors. Beside the digestion and absorption of nutrients, it also acts as barrier to allergens, pathogens, toxins. Leaky gut syndrome is defined mucosal dysfunction, which results in abnormally increased intestinal permeability. Research shows leaky (LGS) has pathogenetic relationship series gastrointestinal ext...

The patient is a 12 year-old girl who has been suffering from episodes of in testinal obstruction since she was 6 years old, leading to severe malnutrition, malabsorption and growth retardation.  Repeated radiological examinations revealed esophageal achalasia, gastric distention, marked small intestinal and mild colonic dilatation. Transmural biopsies from small and large bowels showed normal ...

The intestinal epithelium forms an essential element of the mucosal barrier and plays a critical role in the pathophysiological response to different enteric disorders and diseases. As a major enteric dysfunction of the intestinal tract, inflammatory bowel disease is a genetic disease which results from the inappropriate and exaggerated mucosal immune response to the normal constituents in the ...

Intestinal inflammation alters the contractile activity of intestinal smooth muscle. Motility disorders of the gastrointestinal tract are clinically important symptoms, because they are often associated with severe interstitial inflammation. In addition, the motility disorders secondarily induce abnormal growth of the intestinal flora, and the resulting disturbance of this flora aggravates the ...

The gastro-intestinal disorders are the most frequent conditions saw in the gastro-enterology hone. These disorders incorporate gastric tumor, ulcerative colitis, colorectal growth, peptic ulcer, gastroenteritis, an infected appendix and so on and are happening with expanding recurrence. Different elements incorporating changes in nourishment propensities, utilization of medications like cannab...

he incidence of the diverticulum of the small bowel varies from 0.2-1.3% in autopsy studies to 2.3% when assessed on enteroclysis. it occurs mostly in patients in the 6th decade of their life. of all the small bowel diverticuli, jejunal diverticulum is the most common type. this rare entity is usually asymptomatic. however, they may cause chronic non-specific symptoms for a long period of time ...

Objective of the Review: To discuss changes in intestinal microbiota various diseases. Key Points. Microbial imbalance plays an important role pathogenesis and/or progression a number diseases, namely Clostridium difficile-associated disorders, inflammations, obesity, colorectal cancer, autistic disorders and other. Moreover, therapies involving faecal transplantation, use pro- prebiotics, meta...

The review article presents current data on the possible connection between occurrence of allergies and disorders in intestinal microbiota. role microbiota development immune system a child, as well maintenance its tolerance, is discussed. Factors whose effects can be associated with changes allergic diseases are considered.