This study investigates the separate effects of age and hepatocellular liver disease on the disposition and elimination of diazepam (Valium) in man. The drug was given either by rapid intravenous injection (0.1 mg/kg) or orally (10 mg) to 33 normal volunteers rnaging in age from 15 to 82 yr as well as to 9 individuals with alcoholic cirrhosis, 8 with acute viral hepatitis, and 4 with chronic ac...

1. After a fixed weight-related dose given intravenously, plasma diazepam concentrations were significantly lower in 11 cirrhotic patients than in controls matched for age and sex, in the 4 h after diazepam administration but not thereafter. 2. When measured at a single fixed time point, a greater proportion of the drug was in the unbound from in the plasma of cirrhotic patients, but non-bound ...

Pulmonary aspiration occurred in 16 out of 65 patients (24.6%) undergoing fibre-endoscopic examinations of the upper gastrointestinal tract under intravenous sedation, but it was rarely followed by serious complications. Aspiration was found to occur under sedation with diazepam alone, diazepam with atropine, and with chlormethiazole. The most important factors contributing to aspiration are th...

Infusion thrombophlebitis is a common but illunderstood complication (4, 6) of intravenouS infusions. Further drugs given in infusions may cause phlebitis. Confilicting reports are available about the incidence of phlebitis with diazepam, (1,2,5). Even commonly used antibiotics like ampicillin, in infusion increases the incidence of thrombophlebitis and worst offenders are cephalosporins, (5). ...

objective: patients with conversion disorder may be seen by different specialists in various clinics and emergency situations. however, there are not sufficient studies on the most effective treatment for this disabling illness. methods: in a clinical trial, we compared four treatment strategies muscle relaxation, suggestion, hypnosis and intravenous diazepam infusion, in 80 patients with acute...

The effect of diazepam on the lower oesophageal sphincter (LOS) pressure is controversial. Therefore, a double-blind crossover study was performed on 18 healthy volunteers to determine the sphincter response to intravenous diazepam--70, 140, 280 microgram/kg, which correspond to a total dose of 5, 10, and 20 mg. respectively. After the 5 and 10 mg dose no signficant effect on LOS pressure could...

organophosphorous compounds have been employed as pesticides and chemical warfare nerve agents. toxicity of organophosphorous compounds is a result of excessive cholinergic stimulation through inhibition of acetyl cholinesterase. clinical manifestations include cholinergic syndromes, central nervous system and cardiovascular disorders. organophosphorous pesticide poisonings are common in develo...