نتایج جستجو برای: isis

تعداد نتایج: 2014  

2011
Pavel Semenchuk

The development of Latvian State E-service was started in January, 2006 (Integrated State Information System (ISIS, Latvian abbreviation IVIS)). The customer and provider of the system is Secretariat of Special Assignments Minister for Electronic Government Affairs (SSAMEGA)). Since the middle of 2007 the infrastructure is accessible for E-service designers and developers. ISIS is based on Serv...

Journal: :The Journal of pharmacology and experimental therapeutics 2014
Frank Rigo Seung J Chun Daniel A Norris Gene Hung Sam Lee John Matson Robert A Fey Hans Gaus Yimin Hua John S Grundy Adrian R Krainer Scott P Henry C Frank Bennett

Spinal muscular atrophy (SMA) is a debilitating neuromuscular disease caused by the loss of survival of motor neuron (SMN) protein. Previously, we demonstrated that ISIS 396443, an antisense oligonucleotide (ASO) targeted to the SMN2 pre-mRNA, is a potent inducer of SMN2 exon 7 inclusion and SMN protein expression, and improves function and survival of mild and severe SMA mouse models. Here, we...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 1998
J M Leeds S P Henry S Bistner S Scherrill K Williams A A Levin

The kinetics of an intravitreally administered phosphorothioate oligonucleotide, ISIS 2922, were studied in cynomolgus monkeys. Vitreal and retinal concentrations were measured after administration of 11, 57, or 115 microg/eye. ISIS 2922 concentrations in vitreous and retina were compared, after single, weekly, or biweekly doses, for potential accumulation. ISIS 2922 levels were quantified usin...

Journal: :The Journal of infectious diseases 1997
M Flores-Aguilar G Besen C Vuong M Tatebayashi D Munguia P Gangan C A Wiley W R Freeman

Retinal toxicity of ISIS 2922 and ISIS 4015, phosphorothioate oligonucleotides complementary to human cytomegalovirus (CMV) and herpes simplex virus (HSV) RNA, were evaluated. The intravitreal concentration of ISIS 2922 found not to cause permanent toxic changes in the rabbit retina was 10 microM and in the pig retina, 5 microM. The 3 microM concentration was associated with a transient inflamm...

Journal: :The Journal of biological chemistry 1991
M Y Chiang H Chan M A Zounes S M Freier W F Lima C F Bennett

Intercellular adhesion molecule 1 (ICAM-1) is a glycoprotein expressed on the surface of both hemopoietic and nonhemopoietic cells that mediates, in part, the emigration of leukocytes out of the vasculature. Expression of ICAM-1 on the surface of human umbilical vein endothelial cells and a human lung carcinoma cell line (A549) was increased by interleukin-1 beta, tumor necrosis factor alpha, a...

2015
Marshelle S Warren Steven G Hughes Walter Singleton Mason Yamashita Mark C Genovese

INTRODUCTION This randomized, double-blind, phase II study evaluated the pharmacodynamics, safety and tolerability of ISIS 329993 (ISIS-CRPRx), an antisense oligonucleotide, in patients with active rheumatoid arthritis (RA). METHODS Patients with active RA of at least six months duration were randomized into three cohorts to receive ISIS-CRPRx (100 mg, 200 mg or 400 mg) or placebo (3 active:1...

Journal: :Antimicrobial agents and chemotherapy 1993
L M Cowsert M C Fox G Zon C K Mirabelli

Papillomaviruses induce benign proliferative lesions, such as genital warts, in humans. The E2 gene product is thought to play a major role in the regulation of viral transcription and DNA replication and may represent a rational target for an antisense oligonucleotide drug action. Phosphorothioate oligonucleotides complementary to E2 mRNAs were synthesized and tested in a series of in vitro bo...

Journal: :Journal of Terrorism Research 2017

Journal: :Journal of Modern Languages 2022

International media have reported on the Islamic State of Iraq and Al-Sham (ISIS), an international terrorist organisation based in Syria since 2014. Women, often young unmarried, were leaving their homes families to sneak into join ISIS, according reports (Neumann, 2015). Sjoberg &Gentry (2011) assert that media's portrayal female terrorists factors encourage women support organisations no...

2016
Hassan Saif Miriam Fernández Matthew Rowe Harith Alani

From its start, the so-called Islamic State of Iraq and the Levant (ISIL/ISIS) has been successfully exploiting social media networks, most notoriously Twitter, to promote its propaganda and recruit new members, resulting in thousands of social media users adopting pro-ISIS stance every year. Automatic identification of pro-ISIS users on social media has, thus, become the centre of interest for...

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