In the present study, we investigated the effect of a new anticancer Pd(II) complex, 1,10-phenanthroline-n-butyl dithiocarbamato Pd(II) nitrate, on the heme releasing from human hemoglobin (Hb) as well as alterations in the structure and function of Hb using different spectroscopic methods of UV-Vis, fluorescence and circular dichroism (CD)at two temperatures of 25 and 37 °C. Fluorescence data ...

objective: to compare immunogenicity of a recombinant hepatitis b (hb) vaccine in two groups of neonates born in two cities of iran with different geographic and ethnic backgrounds.   materials and methods: ten micrograms of a recombinant hb vaccine was administered under field condition to iranian healthy neonates at 0, 1.5 and 9 months intervals. the subjects consisted of two groups of 290 an...

Two human hemoglobins designed to inhibit the polymerization of sickle hemoglobin (Hb S; alpha 2 beta S2) have been produced. Mutations that disrupt the ability of Hb S to form polymers were introduced into the normal human beta-globin gene by site-specific mutagenesis. These mutations affect the axial and lateral contacts in the sickle fiber. The recombinant hemoglobin designated anti-sickling...

INTRODUCTION Hepatitis B virus (HBV) is a DNA virus which is highly host and organ specific; to date it has only been found to infect hepatocytes of man and of a few nonhuman primate species. Despite the continuing failure of virologists to find an in vitro system for propagating HBV, it has been possible to gain a great deal of information about the agent and about viral hepatitis, type B, as ...

BACKGROUND The epidemiological impact and the duration of protection provided by infant hepatitis B (HB) vaccination are unknown. OBJECTIVES This study was designed to determine the hepatitis B virus (HBV) infection seromarkers in young adults who have been vaccinated against HBV as the first group of Iranian neonates during 1993 and 1994. PATIENTS AND METHODS We recruited 510 young adults ...

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the epidermal growth factor family and has a variety of physiological and pathological functions. Modulation of HB-EGF activity might have a therapeutic potential in the oncology area. We explored the therapeutic possibilities by characterizing the in vitro biological activity of anti-HB-EGF monoclonal antibody Y...

Haptoglobin (Hp) counterbalances the adverse effects of extra-erythrocytic hemoglobin (Hb) by trapping ?? dimers Hb in bloodstream. In turn, Hp:Hb complexes display Hb-like reactivity. Here, kinetics NO dissociation from ferrous nitrosylated (i.e., Hp1–1:Hb(II)-NO and Hp2–2:Hb(II)-NO, respectively) are reported at pH 7.0 20.0 °C. Hp:Hb(II)-NO has been followed replacing with CO. Denitrosylation...

Background: The outcome of Hepatitis B virus (HBV) infection is chronic or resolved HBV infection. Over the time, the levels of HBsAg or Anti-HBs declined and were not detectable in their sera and was named as isolated anti-HBc. The purpose of this study was to assess the prevalence of isolated anti-HBc in previously HBV infected individuals.Methods: From April 2000 to September 2008, the resul...

Superoxide ions (O2-) oxidized oxyhaemoglobin to methaemoglobin and reduced methaemoglobin to oxyhaemoglobin. The reactions of superoxide and H2O2 with oxyhaemoglobin or methaemoglobin and their inhibition by superoxide dismutase or catalase were used to detect the formation of superoxide or H2O2 on autoxidation of oxyhaemoglobin. The rate of autoxidation was decreased at about 35% in the prese...

BACKGROUND Little is known about duration of protection after the infant primary series of hepatitis B (HB) vaccine in settings of low HB endemicity. This study sought to determine the proportion of adolescents immunized as infants who had protective titers of antibody to hepatitis B surface antigen (anti-HBs) before and after a challenge dose of vaccine. METHODS US-born 16- through 19-year-o...