Withania somnifera (WS) (Dunal) or Ashwagandha is a well-known hypolipidemic herb and antioxidant. In this study, 75% ethanolic extract of WS attempted to evaluate the cardioprotective activity isoproterenol-induced cardiotoxicity in Triton WR 1339-induced hyperlipidemia. addition, phytochemical evaluation same extracts analyzed by gas chromatography–mass spectrometer (GC–MS). This study found ...

The current investigation was proposed to assess the effectiveness of combination resveratrol and ascorbic acid against Isoproterenol (ISO)-induced myocardial infarction in rats. experimental model divided into six groups (n = 6 each group). Group I: control, 2: isoproterenol (ISO)-100 mg/kg b.wt, 3: ISO+Resveratrol (RES) (20 b.wt) treated, 4: ISO+ Ascorbic (AA) (80 5: ISO+RES b.wt)+AA treated ...

Although β1-adrenoceptor (β1-AR) signal transduction, which maintains cardiac function, is downregulated in failing hearts, the mechanisms for such a defect heart failure are not fully understood. Since hypertrophy invariably associated with failure, it possible that loss of β1-AR occurs due to hypertrophic process. In this regard, we have reviewed information from rat model adaptive and malada...

The aim of present study was to investigate whether food restriction combined with exercise training could attenuate the oxidative stress and promote angiogenesis in a rat model of heart failure. 50 male wistar rats weighing 250-300 g were randomly divided into 5 groups including: 1) sham; they were fed ad libitum food, n=10. 2) Heart failure group; 3) Exercise group; they run on a treadmill 5 ...

Background: There are controversial reports about the exact mechanisms of lead-induced hypertension, but many factors such as alteration in the responsiveness of cardiovascular system to endogenous substances including catecholamines could be one of the mechanisms involved. In present study, the effect of exposure to 100 ppm lead acetate by drinking water (in the periods of 4, 8 and 12 weeks)...

In animals injected with a bolus of isoproterenol, fi-adrenergic receptors in both mononuclear leukocytes (MNL) and heart were sequestered away from the cell surface, and the time course (0-120 min) and dose-response patterns were similar in the two tissues. In guinea pigs given a constant infusion of isoproterenol, 0.15 mg/(kg * h), down-regulation of total receptor number occurred more quickl...

RATIONALE β-Adrenoceptor activation contributes to sudden death risk in heart failure. Chronic β-adrenergic stimulation, as occurs in patients with heart failure, causes potentially arrhythmogenic reductions in slow delayed-rectifier K(+) current (IKs). OBJECTIVE To assess the molecular mechanisms of IKs downregulation caused by chronic β-adrenergic activation, particularly the role of exchan...

Children with heart failure are treated with similar medical therapy as adults with heart failure. In contrast to adults with heart failure, these treatment regiments are not associated with improved outcomes in children. Recent studies have demonstrated age-related pathophysiological differences in the molecular mechanisms of heart failure between children and adults. There are no animal model...

Loss of cardiac myocytes in heart failure is thought to occur largely through an apoptotic process. Here we show that heart failure can also be precipitated through myocyte necrosis associated with Ca2+ overload. Inducible transgenic mice with enhanced sarcolemmal L-type Ca2+ channel (LTCC) activity showed progressive myocyte necrosis that led to pump dysfunction and premature death, effects th...