Three patients developed autoimmune haemolytic anaemia while being treated with mefenamic acid. In each case the autoimmune haemolytic anaemia was of the warm antibody gammaG type, and the antibodies had some rhesus specificity. All three patients recovered when the drug was withdrawn.Attempts to inhibit or enhance the activity of the antibody in vitro were unsuccessful.Direct antihuman globuli...

The methods for quantitative determination of meloxicam and mefenamic acid in pharmaceuticals by classic spectrophotometry - zero order derivative, first and second order derivatives spectrophotometry is described, using "peak - peak" (P-P) and "peak - zero" (P-O) measurements. The calibration curves are linear within the concentration range of 4.0 - 14.0 microg/mL for meloxicam and 14.0 - 24.0...

A new compound of Mefenamic Acid derivate, 4-nitrobenzoyl-mefenamic acid has been synthesized by benzoylation reaction between mefenamic acid and 4-nitrobenzoyl chloride after prediction by in silico study/molecular approach. A derivative of mefenamic acid (4-NO2-benzoyl-mefenamic acid) has been synthesized for increase its activity as candidate of analgesic drug/inhibitor COX-2 (Cyclooxigenase...

abstract background: different therapeutic methods have been applied for the treatment of dysmenorrhea and the method with the lesser side effects is preferred. the aim of this study was to compare the effects of herbal products (fennelin and vitagnus) and mefenamic acid in the treatment of primary dysmenorrhea. materials and methods: this double-blind clinical trial was carried out in 105 stud...

Article history: Received on: 17/09/2014 Revised on: 04/10/2014 Accepted on: 23/10/2014 Available online: 29/12/2014 A simple, RP-HPLC stability indicating method was developed for determination of mefenamic acid in pharmaceutical formulations and its degradation products using C8 column with the mobile phase containing mixture of Buffer : Acetonitrile + THF in the ratio of 55:45 v/v at a flow ...

It is well accepted that bacterial and virus infections elevate the levels of cytokines in serum and cerebrospinal fluids. Such high levels of cytokines might alter the integrity of the blood-brain barrier (BBB) and/or blood-cerebrospinal fluid barrier (BCSFB), subsequently affecting brain penetration of drugs. However, few reports have addressed this issue. Thus, we investigated brain penetrat...

In the present investigation mefenamic acid prodrug of ß-cyclodextrins was synthesized. The primary hydroxy group of ß-cyclodextrins was used to block the acid group. The synthesis involved a series of protection and deprotection reaction. The ester was evaluated for stability in simulated gastric and intestinal fluid. The hydrolysis of cyclodextrin conjugate in colon is confirmed by the hydrol...