signs and symptoms of d ph toxicity were seen in an epileptic child who had received dph and mp concurrently. in the absence of liver and kidney disease and any intercurrent infection, and with the patient's recovery following the withdrawal of dph, it appears that drug-drug interaction is the most logical explanation for dph intoxication.

conclusions the results of this study supported the potential protective effects of zncl2 on rat kidney tissues against cdcl2 toxicity. results in contrast to the animals that received zncl2, cdcl2 induced a dose-dependent elevation in bun, creatinine, and mda in those without zncl2 pretreatment. zinc chloride had significantly decreased all biochemical parameters and protected kidney cells aga...

UNLABELLED Renal toxicity associated with small-molecule radionuclide therapy has been shown to be dose-limiting for many clinical studies. Strategies for maximizing dose to the target tissues while sparing normal critical organs based on absorbed dose and biologic response parameters are commonly used in external-beam therapy. However, radiopharmaceuticals passing though the kidneys result in ...

A critical comparison of studies that have investigated tissue accumulation and toxicity of TiO2-NPs in fish is necessary to resolve inconsistencies. The present study used identical TiO2-NPs, toxicological endpoints, and fish (juvenile rainbow trout Oncorhynchus mykiss) as previous studies that investigated waterborne and dietary toxicity of TiO2-NPs, and conducted a critical comparison of res...

Nuvan (DDVP) is a member of organophosphorus compounds. It is extremely toxic to insects and is widely used as insecticides. Nuvan has been taken for the acute toxicity to a fresh water fish Channa punctatus LC50 value calculated for the acute toxicity, which were 0.024 ml/L. Histopathological study of kidney and liver after 24hr, 48hr, 72hr and 96hr exposure to acute toxicity of Nuvan. Treatme...

Using twenty chemicals commercially available or provided by NCI, we demonstrated the feasibility of using zebrafish embryos to study toxicity response by assessing Median Lethal Concentration (LC50), developmental teratogenicity, and specific liver and kidney toxicity. For the twenty compounds used to study LC50 and liver and kidney toxicity in zebrafish embryos, we found good correlation with...

Background: The leaf extract of Croton zambesicus (CZ) is used in traditional medicine for the management of various conditions including kidney disease. The purpose of this study was to determine the protective effects of leaf extract of CZ on rat kidney toxicity induced by carbon tetrachloride. Method: Male albino rats were divided into 6 groups of 5 rats and treated for 5 days with aqueous ...

Diazinon is an organophosphate which is extensively used in trade and agriculture. Due to its widespread application, its toxicity is common. Several studies have shown that organophosphates are able to induce oxidative stress by generating free radicals and depletion of endogenous antioxidants. Pomegranate seed oil (PSO) possesses anti-inflammatory and antioxidant effects. In this study, the e...