It has been shown that L-arginine like the abused drugs could release dopamine from meso-cortico-limbic system. The purpose of the present study was to compare the effect of L-arginine with morphine as a standard abuse drug in the induction of conditioned place preference (CPP) in rat. For this purpose, male Wistar rats (250-300 g) were used in the experiments. Five days after surgical cannulat...

magnetic cufe2o4 nanoparticles were synthesized by a facile microwave-assisted reaction between cu(no3)2 and fe(no3)3. the magnetic nanoparticles were added to starch to make magnetic polymeric nanocomposite. the nanoparticles and nanocomposites were characterized using x-ray diffraction and scanning electron microscopy. the magnetic properties of the samples were investigated using an alternat...

Lectin-like oxidized low-density lipoprotein receptor (LOX-1) is a newly identified endothelial cell surface major receptor for oxidatively modified low-density lipoprotein. Progression of arthrosclerosis in the donor organ after organ transplantation is a major problem. We hypothesized that ischemia-reperfusion induces LOX-1. After 1 h ischemia of bilateral kidneys plus 3, 6, or 12 h reperfusi...

To enhance tumor magnetic resonance imaging (MRI) signals via the selective accumulation of contrast agents, we prepared folate-modified gadolinium-lipid-based nanoparticles as MRI contrast agents. Folate-modified nanoparticles were comprised of polyethylene glycol (PEG)-lipid, gadolinium diethylenetriamine pentaacetic acid lipid, cationic cholesterol derivatives, folate-conjugated PEG-lipid, a...

A biocompatible, multimodal, and theranostic functional iron oxide nanoparticle is synthesized using a novel water-based method and exerts excellent properties for targeted cancer therapy, and optical and magnetic resonance imaging. For the first time, a facile, modified solvent diffusion method is used for the co-encapsulation of both an anticancer drug and near-infrared dyes. The resulting fo...