purpose: to report the efficacy of a single intravitreal injection of bevacizumab (ivb) alone or in com-bination with intravitreal triamcinolone acetonide (ivt) versus macular laser photocoagulation (mpc) as primary treatment for diabetic macular edema (dme). methods: this randomized three-arm clinical trial included 103 eyes of 97 patients with clinically significant dme and no previous treatm...

Purpose To investigate the effect of the vascular adhesion protein-1 (VAP-1) inhibitor RTU-1096 on retinal morphologic changes and ocular inflammation after retinal laser photocoagulation in mice. Methods C57BL/6JJcl mice were fed a diet containing RTU-1096, a specific inhibitor for VAP-1, or a control diet ad libitum for 7 days. Laser photocoagulation was performed on the peripheral retina o...

f l t i s e r m s c i t d o o ( t m s a e Diabetic retinopathy (DR) remains the leading cause of blindness among working-age people in developed countries1. Tight control of blood glucose levels and blood pressure is essential for preventing or arresting DR development. However, therapeutic objectives are difficult to achieve and DR therefore occurs in a high proportion of patients. Once DR app...

In a retrospective study in preterms treated with either cryotherapy (n= 16, 2000-2001) or laser photocoagulation (n= 19, 2002-2005) for threshold retinopathy, a significant decrease in duration of postoperative ventilation, in postoperative administration of analgesics and in time until regain of full enteral feeding was documented in infants who received laser photocoagulation. We therefore c...

AIMS To determine the effect of modified macular grid photocoagulation in patients with refractory macular oedema due to uveitis or cataract extraction. METHODS In this study 20 patients with macular oedema underwent modified macular grid laser photocoagulation and were followed by means of standardised examinations (day 0, months 2, 6, and 12) consisting of best corrected visual acuity and f...

PURPOSE To examine whether laser photocoagulation increased production of growth factors and cytokines, especially transforming growth factor-beta 2 (TGF-beta 2), by cultured human retinal pigment epithelial (RPE) cells. METHODS Dot blot analysis was performed to identify the changes using the conditioned medium of cultured human RPE cells with or without laser photocoagulation. The following...

f l t i s e r m s c i t d o o ( t m s a e Diabetic retinopathy (DR) remains the leading cause of blindness among working-age people in developed countries1. Tight control of blood glucose levels and blood pressure is essential for preventing or arresting DR development. However, therapeutic objectives are difficult to achieve and DR therefore occurs in a high proportion of patients. Once DR app...

OBJECTIVE To report the management of retinal angiomatous proliferation (RAP), a recently described intraretinal neovascular lesion occurring in age-related macular degeneration. METHODS This was a retrospective review of consecutive patients with age-related macular degeneration who underwent treatment of RAP from January 1, 2000, through January 31, 2003. Inclusion criteria were age 55 year...

This study was designed to evaluate the inhibitory effect of endostatin on choroidal neovascularization (CNV) in laser-induced rat model. Choroidal neovascularization was induced in Brown Norway (BN) rats by diode-laser photocoagulation. Rats were randomly divided into five groups (10 animals in each group): endostatin 20mg/kg group, endostatin 10mg/kg group, laser injury group, normal saline g...