نتایج جستجو برای: limb bud cells

تعداد نتایج: 1455027  

خاکساری, دکتر محمد , رضازاده , دکتر مجتبی , شریعتی , مهدی ,

ABSTRACT: Retinoic acid "one of the derivatives of vitamin A "has different morphogenic and teratogenic effects on developing organs. For this reason, the present study is an attempt to examine the effects of retinoic acid on limb bud ,eye and body axis of chick embryo in the stages of 11-12 Humburger and Hamilton. The experiments cartied out in this study was based on 140 white eggs which h...

Journal: :Development 1996
G Daston E Lamar M Olivier M Goulding

The limb muscles of vertebrates are derived from precursor cells that migrate from the lateral edge of the dermomyotome into the limb bud. Previous studies have shown that the paired domain-containing transcription factor Pax-3 is expressed in the limb in cells that are precursors for limb muscles (Williams, B. and Ordahl, C.P. (1994) Development 120, 785-796). In splotch (Pax-3-) embryos, the ...

Journal: :Development 1992
J C Izpisúa-Belmonte J M Brown A Crawley D Duboule C Tickle

The products of Hox-4 genes appear to encode position in developing vertebrate limbs. In chick embryos, a number of different signalling regions when grafted to wing buds lead to duplicated digit patterns. We grafted tissue from the equivalent regions in mouse embryos to chick wing buds and assayed expression of Hox-4 genes in both the mouse cells in the grafts and in the chick cells in the res...

Journal: :Cell Biochemistry and Function 2021

The freshwater crayfish is capable of regenerating limbs, following autotomy, injury and predation. In arthropod species, regeneration moulting are two processes linked strongly regulated by ecdysone. limbs divided into wound healing, blastema formation, cellular reprogramming tissue patterning. Limb cells undergo proliferation, dedifferentiation redifferentiation. A limb bud, containing folded...

Journal: :Mechanisms of Development 2006
Shu-hsuan Claire Hsu Babak Noamani Danielle E. Abernethy Hui Zhu Giovanni Levi Andrew J. Bendall

During endochondral ossification in the vertebrate limb, multipotent mesenchymal cells first differentiate into chondroblasts (chondrogenesis) that further differentiate (via chondrocyte hypertrophy) to a terminal cellular phenotype. Dlx5 and Dlx6 are functionally redundant regulators of chondrocyte hypertrophy. We now show that Dlx5 and Dlx6 also regulate the earlier step of chondrogenesis in ...

2017
ROY A. TASSAVA

Monoclonal antibody WE3 (mAb WE3) reacts to the majority of cells of the wound epithelium during limb regeneration, but to only a small minority of cells of skin epidermis. Since both the apical ectoderm of the limb bud and the wound epithelium of regenerating limbs are important to limb outgrowth, it was of interest to determine whether the WE3 antigen was shared by these two developmentally i...

Journal: :Development 1993
R Anderson M Landry K Muneoka

The positional signal localized to the posterior (zone of polarizing activity or ZPA) region of the vertebrate limb is transiently expressed during development and a decline in ZPA signaling is accelerated when posterior cells are dissociated and cultured in vitro. The evidence that cultured posterior cells display a precocious decline in ZPA signaling when compared to in vivo studies suggests ...

2010
Antonella Galli Dimitri Robay Marco Osterwalder Xiaozhong Bao Jean-Denis Bénazet Muhammad Tariq Renato Paro Susan Mackem Rolf Zeller

The polarization of nascent embryonic fields and the endowment of cells with organizer properties are key to initiation of vertebrate organogenesis. One such event is antero-posterior (AP) polarization of early limb buds and activation of morphogenetic Sonic Hedgehog (SHH) signaling in the posterior mesenchyme, which in turn promotes outgrowth and specifies the pentadactylous autopod. Inactivat...

Journal: :Molecular and cellular biology 2004
Christopher T Lee Luoping Li Norio Takamoto James F Martin Francesco J Demayo Ming-Jer Tsai Sophia Y Tsai

The nuclear orphan receptor COUP-TFII is widely expressed in multiple tissues and organs throughout embryonic development, suggesting that COUP-TFII is involved in multiple aspects of embryogenesis. Because of the early embryonic lethality of COUP-TFII knockout mice, the role of COUP-TFII during limb development has not been determined. COUP-TFII is expressed in lateral plate mesoderm of the ea...

Journal: :Current Biology 1996
Thomas Stratford Claire Horton Malcolm Maden

BACKGROUND Retinoic acid (RA) is present in the chick limb bud, and excess RA induces limb duplications. Here, we have investigated the role of endogenous RA during chick limb development by preventing the synthesis of RA and testing the effect on various genes expressed during limb initiation and outgrowth. RESULTS We demonstrate that the stage 20/21 limb bud synthesizes didehydroretinoic ac...

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