نتایج جستجو برای: line chemotherapy
تعداد نتایج: 514303 فیلتر نتایج به سال:
CONTEXT In the last decade, gemcitabine-based regimen as first-line therapy has demonstrated low efficacy regarding overall survival benefit for patients with advanced pancreatic cancer. OBJECTIVE The purpose of this study was to explore a new strategy, such as an increased second-line chemotherapy rate, in order to improve overall survival. DESIGN Retrospective data analysis. METHODS The...
Although crizotinib has demonstrated promising efficacy and acceptable toxicity in patients with advanced non-small cell lung cancer (NSCLC), the available evidence in Chinese populations is currently limited. This study compared the progression-free survival (PFS) of Chinese patients with anaplastic lymphoma kinase (ALK)-positive, advanced lung adenocarcinoma who received first-line crizotinib...
We assessed the use and outcomes of first-, second- third-line chemotherapy in patients diagnosed with hormone receptor-positive/HER2-negative (HR+/HER2-) advanced breast cancer (ABC). All consecutively HR+/HER2-ABC 2007-2020 ten Dutch hospitals were retrieved from SONABRE registry (NCT-03577197). Last follow-up was collected 2022. The proportion starting a specific line using competing risk me...
BACKGROUND After progression to a standard first-line platinum and gemcitabine combination (GP), there is no established second-line therapy for patients with advanced biliary tract cancers (aBTC). Indeed, literature data suggest limited activity of most second-line agents evaluated so far. METHODS We collected a large retrospective series of aBTC patients treated with second-line chemotherap...
Patients with "difficult-to-treat" advanced testicular cancer can require multiple therapies. We retrospectively assessed our patients with advanced germ cell tumors (GCTs) and characterized the clinical efficacy, outcomes, and factors affecting overall survival (OS).Two hundred fifty-three patients with advanced GCTs were treated at Kyoto Prefectural University of Medicine, Kyoto, Japan, from ...
Platinum-based chemotherapy regimens are frequently used in patients with triple-negative breast cancer (TNBC). The aim of the current study was to assess whether or not platinum-based chemotherapy is associated with an increased time to progression when compared with non-platinum-based regimens in TNBC and non-TNBC. A retrospective analysis was conducted within a cohort of patients with metast...
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