background: transient elastography (te) is a new modality for the diagnosis of liver fibrosis caused by various etiologies. this study was conducted to determine the accuracy of te in detecting the different stages of liver fibrosis in non-alcoholic fatty liver disease (nafld) patients. methods: medline/pubmed, embase, ovid, cochrane library, american college of physicians (acp) journal club, g...

background: the mean platelet volume (mpv) is the most commonly used measure of platelet size and is a potential marker of platelet reactivity. in this study, we aimed to explore the relationship between hepatic  histopathology in viral hepatitis and mpv levels,which are associated with platelet count and activity. materials and methods: we performed a retrospective case-control study of baseli...

: This paper aims to analyze how intestinal flora regulates liver fibrosis pathogenesis and evaluate the regulatory effect of traditional Chinese medicine (TCM) on flora, providing new insights into treatment. Destruction microbiome can lead development, accelerating microbiome’s disruption. TCM effectively regulate helping prevent treat fibrosis. review discusses mechanisms behind changes in t...

conclusions this study revealed that serum iron markers (especially ferritin and transferrin) might be used as surrogate markers for both liver fibrosis and necroinflammatory activity. patients and methods eighty five patients with untreated hepatitis c chronic infection were investigated. . results twenty one patients (24.7%) had elevated serum iron levels, and 29 subjects (34.1%) had severe l...

background: â  advanced hepatic fibrosis and cirrhosis has generally been considered to be irreversible. the aim of this study was to determine whether cirrhosis is reversible.â  â  methods: â  seven patients with autoimmune hepatitis with histologic evidence of cirrhosis were enrolled. after treatment, they had follow-up liver biopsy while in clinical and biochemical remission. biopsy specimen...

Background & Aim: Bombax costatum stem bark is traditionally used in treatment of liver diseases but the anti-hepatofibrotic effect of its ethyl acetate fraction has not been scientifically evaluated. This study aimed to evaluate the anti-hepatofibrotic effect of ethyl acetate fraction of B. costatum stem bark (EAB) against carbon tetrachloride (CCl4) induced liver fibrosis in mice. Experimenta...

Liver biopsy is historically the gold standard for liver fibrosis assessment of chronic hepatitis C patients. However, with introduction and validation noninvasive tests (NITs) to evaluate advanced fibrosis, direct-acting antiviral agents treatment virus (HCV), role NITs have become even more complex. There now need longitudinal monitoring elucidation cutoff values prediction liver-related comp...

Macromolecular proton fraction (MPF) and T1rho maps for two representative patients with F0 F2 stage fibrosis as confirmed by liver histology. (A) MPF from a patient fibrosis, (B) (C) the same (D) fibrosis. Jian Hou et al. (485–492).