We present a diagnostically challenging case of 30-year-old twin males with chronic elevated liver enzymes (GGT) without history of hepato-biliary diseases. Genetic study disclosed mutations in gene ABCB11 and liver histopathology shows only scanty fatty change without evidence of fibrosis or malignancy. Liver enzymes level successfully return to normal in 2 moths following ursodeoxycholic acid...

: Hydatid cyst is one of the predominantly cystic liver lesions and also a zoonotic disease that highly endemic in Mediterranean region. This condition has extensive differential diagnoses, such as hepatic mesenchymal hamartoma, rare benign tumor, which commonly occurs infants children, extremely adults. Its imaging findings vary from tumor to solid mass occupying or both lobes liver. We report...

The histopathological changes in Budd–Chiari syndrome (BCS) overlap with those of sinusoidal obstruction (SOS) and cardiac or pericardiac disorders resulting right failure. These conditions, however, are different on both clinical pathological grounds need to be differentiated from BCS. This review is centred the three main aspects BCS diagnostic liver histopathology: (1) general histopathology...

This study was aimed at evaluating the blood glucose level, hepatic biomarkers and histology of alloxan induced diabetic rats fed with Sesamum indicum compounded diet. Thirty-Six male albino were divided into nine groups (normal control, standard drug-glibenclamide treated, 15%, 30% 60% diet normal diabetics after 14 days) four each lasted for 21 days. The induction diabetes done by a single do...

The disposition kinetics of six cationic drugs in perfused diseased and normal rat livers were determined by multiple indicator dilution and related to the drug physicochemical properties and liver histopathology. A carbon tetrachloride (CCl(4))-induced acute hepatocellular injury model had a higher fibrosis index (FI), determined by computer-assisted image analysis, than did an alcohol-induced...

Liver biopsy is still the most accurate tool to assess liver histopathology in chronic liver disease (CLD), especially in patients with chronic active hepatitis who need a treatment decision. Nowadays, there are many non-invasive methods are being used to assess liver fibrosis and might replace liver biopsy. One of the new methods is transient elastography (TE/Fibroscan) which has been widely u...

Background: Alcoholic liver cirrhosis is a common indication for liver transplantation. Recurrence of alcohol use was retrospectively analyzed after liver transplantation. Methods: From X/1995 to II/2002, 42 out of 246 patients underwent liver transplantation for alcoholic liver cirrhosis. We administered a questionnaire to all patients surviving at least 1 year post liver transplantation for a...

Hepatic ischemia-reperfusion (IR) injury is a clinical problem that leads to cellular damage and organ dysfunction mediated mainly via production of reactive oxygen species and inflammatory cytokines. Vinpocetine has long been used in cerebrovascular disorders. This study aimed to explore the protective effect of vinpocetine in IR injury to the liver. Ischemia was induced in rats by clamping th...

Hepatoprotective and curative activities of aqueous extract of decoction containing 10 Chinese medicinal herbs (HPE-XA-08) were evaluated in Sprague-Dawley albino rats with liver damage induced by thioacetamide (TAA). These activities were assessed by investigating the liver enzymes level and also histopathology investigation. Increases in alkaline phosphatase (ALP) and gamma-glutamyl transfera...