Objective(s): The objective of this study was to investigate the hepatoprotective effect of licochalcone B (LCB) in a mice model of carbon tetrachloride (CCl4)-induced liver toxicity. Materials and Methods: Hepatotoxicity was induced in mice by a single subcutaneous injection (SC) of CCl4. The LCB was administered orally once a day for seven days (PO) as pretreatment at three doses of 1, 5, and...

background: finding protective agents with fewer adverse effects against toxin-induced liver injuries, as a key detoxifier and excreter organ, have always been a concern for researchers. carbon tetra-chloride (ccl4)-induced liver damage has been introduced as an experimental model of liver damage. this study aimed to investigate the protective effect of ethanolic extract of zizyphus vulgaris (z...

  In the February 2006 in two wetlands in northern Iran, the mortality among wild swans was observed. Paralysis was the most prominent feature of the disease. Histologically, diffused necrosis of acinar cells in pancreas, degeneration and necrosis of some neurons in central nervous system (CNS), sever necrotic and hemorrhagic enteritis, foci of haemorrahge and myocardial cell necrosis in the he...

Hepatic ischemia-reperfusion (I/R) is a common phenomenon during liver surgery, transplantation, infection and trauma which results in damage and necrosis of the hepatic tissue through different pathways. Mechanisms involved in I/R damage are very intricate and cover several aspects. Several factors are involved in I/R-induced damages; briefly, decrease in sinusoidal perfusion and ATP generatio...

Turmeric (Curcuma longa L.) rhizome contains antioxidant compounds that can prevent damage to the liver. Thioacetamide (TAA) is an organosulfur compound in form of crystals and widely used as a fungicide organic solvent textile, leather paper industries, well being motor fuel stabilizer. Continuous exposure TAA cause hepatocyte parenchymatous degeneration necrosis. The purpose this study was de...

PURPOSE To correlate intra voxel incoherent motion (IVIM) diffusion parameters of liver parenchyma and hepatocellular carcinoma (HCC) with degree of liver/tumor enhancement and necrosis; and to assess the diagnostic performance of diffusion parameters vs. enhancement ratios (ER) for prediction of complete tumor necrosis. PATIENTS AND METHODS In this IRB approved HIPAA compliant study, we incl...

background: a solitary necrotic nodule (snn) of the liver is an uncommon lesion, which is different from primary and metastatic liver cancers. objectives: to analyze the classification, ct and mr manifestation, and the pathological basis of solitary necrotic nodule of the liver (snn) in order to evaluate ct and mri as a diagnosing tool. patients and methods: this study included 29 patients with...