نتایج جستجو برای: loss of function mice mutants
تعداد نتایج: 21309946 فیلتر نتایج به سال:
GPR116 (ADGRF5) and ELTD1 (ADGRL4) belong to different subfamilies of the adhesion G-protein-coupled receptor group but are both expressed in endothelial cells. We therefore analyzed their functions in mice lacking these receptors. While loss of GPR116 or ELTD1 alone had no obvious effect on cardiovascular or kidney function, mice lacking both, GPR116 and ELTD1, showed malformations of the aort...
dendrimer synthesis strategies now provide virtual control of macromolecular nanostructures as a function of size and surface/interior functionality. these strategies involve the covalent assembly of hierarchical components reactive monomers , branch cells or dendron’s around atomic or molecular cores according to divergent/convergent dendrite branching principles.combinon of two or more dendri...
a professional is someone whose work involves performing a certain function with some degree of expertise. but a narrower definition limits the term to apply to people such as teachers and doctors, whose expertise involves not only skill and knowledge but also the exercise of highly sophisticated judgment, and whose accreditation necessitates extensive study, often university-based as well as p...
Transient receptor potential melastatin member 4 (TRPM4) encodes a Ca2+-activated, non-selective cation channel that is functionally expressed in several tissues, including the heart. Pathogenic mutants TRPM4 have been reported patients with inherited cardiac diseases, conduction blockage and Brugada syndrome. Heterologous expression of mutant channels cell lines indicates these mutations can l...
The Golgi is essential for glycosylation of newly synthesised proteins including almost all cell-surface and extracellular matrix proteoglycans. Giantin, encoded by the golgb1 gene, is a member of the golgin family of proteins that reside within the Golgi stack, but its function remains elusive. Loss of function of giantin in rats causes osteochondrodysplasia; knockout mice show milder defects,...
Over 1000 different mutants of the tumor suppressor protein p53 with one amino acid change in the core domain have been reported in human cancers. In mouse knock-in models, two frequent mutants displayed loss of wild-type (wt) p53 function, inhibition of wt p53 and wt p53-independent gain of function. The remaining mutants have been systematically characterized for loss of wt p53 function, but ...
Poinsettia is an economically important ornamental potted plant in which certain bract colour variants are often obtained by mutation breeding. Previously, poinsettia, we identified Bract1, a GST gene involved the sequestration and transport of anthocyanins to vacuole. This carries short, highly mutable 4-bp repeat its coding region. Loss one unit leads loss function for homozygous mutants, ant...
Abstract Invariant Natural Killer T (iNKT) cells are characterized by a semi-invariant TCR and NK markers. They respond to glycolipid antigens presented the major histocompatibility complex (MHC)-like molecule CD1d. Our single-cell transcriptomic profiling of several tissues identified marrow iNKT as unique subset, possibly modulating homeostasis. However, little is known about their role in he...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید