نتایج جستجو برای: matrix metalloproteinase mmp
تعداد نتایج: 374023 فیلتر نتایج به سال:
We report the effect of recombinant human interleukin-1β (IL-1β) on cell morphology and on the pattern of matrix metalloproteinase (MMP) gelatinolytic activity expressed by quiescent and growing human osteoarthritic chondrocytes. After treatment with IL1β, gelatin zymography revealed a significant increase of 64-62 kDa MMP-2 active forms suggesting an overexpression of its activator membrane ty...
Chlamydia (C.) pneumoniae are thought to infect monocytes and use them as vectors into the vessel wall, where they may accelerate atherosclerosis. We investigated the effects of C. pneumoniae on monocytic matrix metalloproteinase (MMP) activation with focus on the role of the extracellular matrix metalloproteinase inducer EMMPRIN. Human monocytes or monocytic MonoMac6 cells were infected with C...
The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade multiple components the extracellular matrix. significant role MMPs in tumor invasion, neoangiogenesis and metastasis presented it as ideal pharmacological targets for cancer therapy. effects ursolic acid (UA) on metalloproteinase (MMP) gene expression, cell invasion migration were investigated MDA MB- 231 lin...
A chondrosarcoma is a common tumor of the soft tissue and bone that has high propensity to metastasize distant organs. Nerve growth factor (NGF) capable promoting progression metastasis several different types tumors although effects NGF in are not confirmed. Here, we found levels matrix metalloproteinase-2 (MMP-2) correlated with stage patients chondrosarcoma. facilitated MMP-2-dependent cellu...
in the human genome, chromosome 11 contains a cluster of matrix metalloproteinase (mmp) genes. single nucleotide polymorphisms in the promoter region of mmp genes are important for mmp expression. a common adenine deletion polymorphism (5a) at position -1171 of the mmp-3 gene promoter (5´-aaaaaaccat-3´ change to 5´-aaaaaccat-3´) facilitates transcriptional factor binding and mmp-3 promoter acti...
Matrix metalloproteinases are zinc-containing enzymes capable of degrading all components of the extracellular matrix. Owing to their role in human disease, matrix metalloproteinase have been the subject of extensive study. A bioinorganic approach was recently used to identify novel inhibitors based on a maltol zinc-binding group, but accompanying molecular-docking studies failed to explain why...
Background and purpose: Matrix metalloproteinase are a family of proteolytic enzymes that have specific functions in digestion of cells cohesive extra cellular matrix and also, increasing metastasis behavior of acute human tumors. It has been reported that MMPs in two forms, namely proenzyme and active enzyme in biological samples. It is distinguished that among this family, (MMP-9) Matrix Me...
BACKGROUND The changes occurring in the rodent uterus after parturition can be used as a model of extensive tissue remodeling. As the uterus returns to its prepregnancy state, the involuting uterus undergoes a rapid reduction in size primarily due to the degradation of the extracellular matrix, particularly collagen. Membrane type-I matrix metalloproteinase (MT1-MMP) is one of the major protein...
Background & Aims: Endometriosis is defined as the presence of tissue resembling endometrium outside the uterine cavity. Extensive remodeling existence in peritoneal mesothelium layer is necessary for adhesion, invasion, and proliferation of endometrial fragments, which is required the activation of matrix metalloproteinase (MMPs), as a normal menstrual cycle. MMPs are a family of zinc dependen...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید