Marek's disease (MD) outbreaks can occur in previously healthy adult layer or breeder flocks. However, it is not clear whether such outbreaks are caused by recent challenge with highly virulent (vv and vv+) strains of MD virus (MDV; i. e., new infection hypothesis) or by exacerbation of an earlier MDV infection (i. e., old infection hypothesis). To discriminate between these hypotheses, adult W...

In a paper published in Nature July 2016, a group of investigators coordinated by the Harvard neuroscientist Eng H. Lo set out to investigated the role of the intercellular transfer of mitochondria from astrocytes to neurons following ischemic stroke [1]. Mitochondria are intracellular organelles involved in several cellular processes, including oxidative phosphorylation, metabolism of amino ac...

Marek's disease (MD) is caused by Marek's disease virus (MDV), a highly cell-associated alphaherpesvirus. MD is primarily characterized by lymphocyte infiltration of the nerves and the development of lymphomas in visceral organs, muscle, and skin. MDV encodes two phosphoproteins, pp24 and pp38, that are highly expressed during lytic infection. These proteins were initially identified in MDV-ind...

Mitochondria are essential organelles that execute and coordinate various metabolic processes in the cell. Mitochondrial dysfunction severely affects cell fitness contributes to disease. Proper organellar function depends on biogenesis maintenance of mitochondria its >1,000 proteins. As a result, has evolved mechanisms protein quality control, such as turnover proteins via mitochondria-associat...