Biomechanical stimuli play important roles in the formation of articular cartilage during early foetal life, and optimal mechanical load is a crucial regulatory factor of adult chondrocyte metabolism and function. In this study, we undertook to analyse mechanotransduction pathways during in vitro chondrogenesis. Chondroprogenitor cells isolated from limb buds of 4-day-old chicken embryos were c...

This study investigated the effect of mechanical load on human mesenchymal stem cell (hMSC) differentiation under different exogenous transforming growth factor-beta1 (TGF-beta(1)) concentrations (0, 1 or 10 ng/ml).The role of the TGF-beta signalling pathway in this process was also studied. Human MSCs were seeded into fibrin-biodegradable polyurethane scaffolds at a cell density of 5 x 10(6) c...

Greater understanding and acceptance of the new concept "bone quality", which was proposed by the National Institutes of Health and is based on bone cells and collagen fibers, are required. The novel protein Semaphorin3A (Sema3A) is associated with osteoprotection by regulating bone cells. The aims of this study were to investigate the effects of mechanical loads on Sema3A production and bone q...

Study about Fracture Mechanics and the root cause of fracture in order to estimates lifetime for Mechanical parts in designing process and manufacturing have tremendous role in this realm. Stress intensity factor comes into design which not only is dependent to geometry also extremely to load condition; for instance, it is important in failure processes (brittle and ductile Materials) or to pre...

Integrative approaches to studying the coupled dynamics of skeletal muscles with their loads while under neural control have focused largely on questions pertaining to the postural and dynamical stability of animals and humans. Prior studies have focused on how the central nervous system actively modulates muscle mechanical impedance to generate and stabilize motion and posture. However, the qu...

structural health monitoring of cracked structures is one of beloved subject of researchers recently. consider of crack behavior in the water and energy pipeline is important because of environmental problems. in this paper consider of crack parameters in the underwater pipe subjected to mechanical transient load is investigated. for this purpose, three- dimensional parametric model of cracked ...

Dynamic emulation of mechanical loads presents a modern and interesting approach for testing and validating performance of electrical drives without a real mechanical load included in the test rig. The paper presents an approach to dynamic emulation of mechanical loads when the load torque and inertia mass of emulated load can be significantly greater than that of laboratory test rig. Closed-lo...

construction of railway embankments on loose beds without using any methods of soil improvement (e.g. stone columns in silt and clay beds, deep soil mixing method, jet grouting and also using micropiles individually or in groups form) leads to  reduction of embankment slope gradient, which significantly increases the volume of soil operation. generally, micropile as a reinforcing element with t...

Resolving molecular determinants of mechanical stability of proteins is crucial in the rational design of advanced biomaterials for use in biomedical and nanotechnological applications. Here we present an interdisciplinary study combining bioinformatics screening, steered molecular dynamics simulations, protein engineering, and single-molecule force spectroscopy that explores the mechanical pro...

A break in the integrity of the plasma membrane immediately compromises this structure’s essential role as a barrier, and this can kill the affected cell. Yet animal cell plasma membranes, unprotected by a cell wall, are highly vulnerable to mechanically induced disruption. Moreover, many tissue environments generate and receive “physiological” levels of mechanical force that impose shear, tens...