Exposure to the sun, ultraviolet radiation, and oxidative stress are the chief etiologic factors responsible for melasma. The ingredients of Korean red ginseng powder, which include ginsenoside and phenolic compounds, have antioxidative effects and reduce ultraviolet B-induced pigmentation. This study was designed to evaluate the effectiveness and safety of Korean red ginseng powder in patients...

Background: Melasma is a common hyperpigmentation disorder that has a significant effect on an individual’s quality of life. However, there is no preference-based measurement that reflects quality of life in patients with melasma. Objectives: To assess the impact of melasma on quality of life by using a health status measurement – the Dermatology Life Quality Index (DLQI) – and a preferencebase...

BACKGROUND Melasma is a common hyperpigmentation disorder that has a significant effect on an individual's quality of life. However, there is no preference-based measurement that reflects quality of life in patients with melasma. The objective of this study was to assess the impact of melasma on quality of life by using a health status measurement - the Dermatology Life Quality Index (DLQI) - a...

Background and purpose: Melasma is a common skin pigmentation disorder that manifests as hyperpigmented macules and patches. Genetic predisposition, sun exposure, and pregnancy are known risk factors for melasma. Previous studies have suggested that thyroid disorders may be associated with melasma. Given the fact that vitamin D affects and stimulates the production of melanin by melanocytes, th...

Melasma is an irregular brown or grayish-brown facial hypermelanosis, often affecting women, especially those living in areas of intense UV radiation. The precise cause of melasma remains unknown; however, there are many possible contributing factors. Because of its dermal component and tendency to relapse, melasma is often difficult to treat. The use of broad-spectrum (UVA + UVB) sunscreen is ...

INTRODUCTION Melasma is a common chronic, acquired pigmentation disorder with a significant impact on the quality of life of patients. AIM To investigate the etiopathogenetic factors, thyroid functions and thyroid autoimmunity in patients with melasma. MATERIAL AND METHODS Forty-five women with melasma and 45 age-matched healthy women were included in the study group. A detailed history was...

BACKGROUND Melasma is an acquired increased pigmentation of the skin characterized by symmetrical and confluent grey-brown patches usually on the areas of the face exposed to the sun. Silymarin strongly prevents photocarcinogenesis, and significantly prevented melanin production. The objectives of this study were the assessment of safety and efficacy of topical Silymain (SM) cream in a double-b...

Background Melasma is a difficult-to-treat hyperpigmentary disorder. Ablative fractional laser (AFL)-assisted delivery of topically applied drugs to varied targets in the skin has been an area of ongoing study and research. Objective The objective of this study was to evaluate the efficacy and safety of fractional erbium-doped yttrium aluminum garnet (Er:YAG) laser as an assisted drug deliver...

BACKGROUND Melasma is a common acquired disorder characterized by symmetric, hyperpigmented patches with an irregular outline, occurring most commonly on the face. It is most prevalent among young to middle-aged women. Although iron overload affects skin pigmentation, effect of iron deficiency on skin is not clear. So, we evaluated serum iron level, ferritin and total iron binding capacity (TIB...

BACKGROUND : Melasma is common and can cause major psychological impact. To date, the mainstay of treatment, including various hypopigmenting agents and chemical peels, is ineffective and can cause adverse effects. Laser is a new approach and is yet to be explored for its efficacy and safety. OBJECTIVE : To compare combined Ultrapulse CO2 laser and Q-switched alexandrite laser (QSAL) with QSA...