Thioridazine (TZ) is used mainly in the treatment of schizophrenia. However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical use. In this context, we examined the cytotoxic mechanisms of TZ on freshly isolated rat hepatocytes to better understanding of the pathogenesis of TZ-induced hepatotoxicity. Hepatocytes were prepared by the method of collagenase enzyme...

Bioartificial liver holds special position in the field of regenerative medicine, and cold environment at 4℃ is widely used for the short storage of both organ and liver cell for later application. However, the disadvantages of such cold storage could influence cell viability and lead to cell apoptosis in different degrees. In this study, we mainly explore the pre-protective effect of mild hypo...

objective: intra-peritoneal administration of riluzole has been shown to preserve the membrane properties and firing characteristics of purkinje neurons in a rat model of cerebellar ataxia induced by 3-acetylpyridine (3-ap). however, the exact mechanism(s) by which riluzole restores the normal electrophysiological properties of purkinje neurons is not completely understood. changes in the condu...

Alveolar membrane stability can be studied by finding out pulmonary surfactant activity (4, 5). Local anaesthetics possess the membrane stabilzing activity. Protective effect of propranolol against adrenaline induced pulmonary edema (APE) has been reported (6, 7). It has been proposed that it may be due to its local anaesthetic acti vity (7), but no experimental evidence was provided. Hence, pr...

objective(s):hypoxia induces cellular oxidative stress that is associated with neurodegenerative diseases. here, the protective effects of ferulic acid (fa) on hypoxia-induced neurotoxicity in pc12 cells were evaluated. materials and methods:we investigated the effect of fa on pc12 cells subjected to hypoxia stress, in vitro. results:fa increased cell viability, prevented membrane damage (ldh r...

Surgical gowns are used as protective clothing in operating room for medical personnel and patients to minimize the transmission of viruses pathogens designed serve a barrier against non-sterile area reduce risk infections. In this study, since disposable provide better effect compared reusable ones, surgical using nonwoven fabric membrane-nonwoven combination were investigated terms their perf...

OBJECTIVE To study the potential protective action in vitro of oviductal epithelial cell membrane proteins against oxidative damage in human spermatozoa. DESIGN Prospective in vitro study. SETTING University research laboratory and infertility clinic. PATIENT(S) Semen from men attending the infertility clinic at the Queen Mary Hospital with normal semen parameters (World Health Organizati...