BACKGROUND AND PURPOSE Mexiletine (Mex), an orally effective antiarrhythmic agent used to treat ventricular arrhythmias, has also been found to be effective for myotonia and neuropathic pain. It is extensively metabolized in humans but little information exists about the pharmacodynamic properties of its metabolites. EXPERIMENTAL APPROACH To determine their contribution to the clinical activi...

Cell cycle lengths vary widely among different cells within an animal, yet mechanisms of cell cycle length regulation are poorly understood. In the Caenorhabditis elegans embryo, the first cell division produces two cells with different cell cycle lengths, which are dependent on the conserved partitioning-defective (PAR) polarity proteins. We show that two key cell cycle regulators, the Polo-li...

To search for use-dependent sodium channel blockers to selectively solve skeletal muscle hyperexcitability in hereditary myotonias, mexiletine (MEX; compound I) and its newly synthetized analogs, 2-(4-chloro-2-methylphenoxy)-benzenethanamine (compound II) and (-)-S-3-(2,6-dimethylphenoxy)-2-methylpropanamine (compound III), were tested on intercostal muscle fibers from the myotonic ADR mouse th...

Introduction: Mars Express (MEX) bistatic radar (BSR) ground tracks will not move to far northern (e.g., Phoenix) latitudes until June 2006. But the generally uniform appearance of these plains areas suggests that certain surface characteristics may be inferred from observations already in hand. Of particular interest are two MEX experiments conducted in the vicinity of the Viking Lander 2 site...

1 Laboratorio de Inmunoparasitoloǵıa, Unidad de Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México, 54090 Tlalnepantla, MEX, Mexico 2Department of Microbiology, Center for Microbial Interface Biology, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA 3Departamento de Inmunoloǵıa, Instituto de Investigaciones Biomédicas, Universi...

BACKGROUND Hypoxia induces an inflammatory response in the lung manifested by alternative activation of macrophages with elevation of proinflammatory mediators that are critical for the later development of hypoxic pulmonary hypertension. Mesenchymal stromal cell transplantation inhibits lung inflammation, vascular remodeling, and right heart failure and reverses hypoxic pulmonary hypertension ...

Abstract The basic idea of Model-Experiment-Exercises (MEX) is to link modelling and experimental works from the very beginning i.e. in conceptual phase. Due complexity each part systems analysis, this combination sometimes lost. Moreover, both models experiments require highly sophisticated tools equipment as well specialized professionals, which also necessitate adequate measures incentives f...