Recently, we demonstrated chromosome instability (CIN) in human cleavage stage embryogenesis following in vitro fertilization (IVF). CIN not necessarily undermines normal human development (i.e. when remaining normal diploid blastomeres develop the embryo proper), however it can spark a spectrum of conditions, including loss of conception, genetic disease and genetic variation development. To s...

DNA microarray technology is one of the major recent advances in biotechnology [1]. In particular, their ability to measure the expression of thousands of genes simultaneously under a certain condition makes them suitable for several biological applications, such as the functional analysis of genes and identification of significantly overor under-expressed genes in complex diseases like cancer....

This paper describes the technology and performance characteristics of the Oligo GEArray® DNA microarray system. Oligo GEArrays® are an effective alternative to genome-wide microarrays, in that each array is designed to profile expression of a focused gene panel from a particular biological pathway or disease state. The data presented in this paper substantiates the sensitivity, reproducibility...

The advent of the DNA microarray technology has brought with it the exciting possibility of simultaneously observing the expression levels of all genes in an organism. One such microarray technology, called "oligo arrays," manufactures short single strands of DNA (called probes) onto a glass surface using photolithography. An altered or missed step in such a manufacturing protocol can adversely...

Does universal preschool constitute an effective policy tool to promote the development and integration of children from minority groups? In the light of rising cross border migration and increasing ethnic variation in many developed countries, we address this question for the children of the Roma the largest and most disadvantaged minority in Europe. To tackle the issue of non-random selection...

objective(s): many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lines is the objective of this research. material and methods:metabolism of c...