objective(s): microarrays are potential analyzing tools for genomics and proteomics researches, which is in needed of suitable substrate for coating and also hybridization of biomolecules.   materials and methods: in this research, a thin film of oxidized agarose was prepared on the glass slides which previously coated with poly-l-lysine (pll). some of the aldehyde groups of the activated agaro...

Background: Idiopathic pulmonary arterial hypertension (PAH) is a potentially fatal vascular disease with an extremely poor natural course. The limitations of current treatment and the unclear etiology pathogenesis idiopathic PAH require new targets avenues exploration involved in PAH. tRNA-derived small RNAs (tsRNAs), type non-coding RNAs, have significant part progress diverse diseases. Howev...

in this paper, we propose a new gene selection algorithm based on shuffled frog leaping algorithm that is called sfla-fs. the proposed algorithm is used for improving cancer classification accuracy. most of the biological datasets such as cancer datasets have a large number of genes and few samples. however, most of these genes are not usable in some tasks for example in cancer classification. ...

an important aspect of microarray studies includes the prediction of patient survival based on their gene expression profile. to deal with the high dimensionality of this data, use of a dimension reduction procedure along with the survival prediction model is necessary. this study aimed to present a new method based on wavelet transform for survival relevant gene selection.the data included 204...

The analysis of gene expression profiles, obtained from DNA microarray experiments, is used to discover relationships between genes and to discern groups of genes involved common processes. The principal aim of this paper is to introduce dynamic modelling of microarray time course data. A novel approach to identify similar gene expression profiles is presented. Using parametric modelling, we de...

Microarray experiments designed to analyze time-series gene expression levels are important to interpret the bacterial gene functions. For this purpose, two-color microarray is indispensable tool for viewing the gene expression changes as snapshot on a large scale. In two-color microarray experiments, differently labeled cDNAs derived from control and target samples are hybridized on an identic...