UNLABELLED MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development. Recently, rs531564/pri-miR-124-1, rs4938723/pri-miR-34b/c, rs7372209/pri-miR-26a-1, rs895819/pre-miR-27a, and rs11134527/pri-miR-218 w...

Objective: To investigate the effect of small nucleolar host gene 12 (SNHG12) on migration and invasion human lung cancer cells by regulating angiostatin binding protein through microribonucleic acid (microRNA)-497. Methods: A549, H1299, PC9 were cultured in Roswell Park Memorial Institute (RPMI)-1640 medium containing 10% fetal bovine serum, bronchial epithelial (HBE) Dulbecco’s modified eagle...

We aimed to characterize early changes in microRNA expression in acute cardioprotection by ischemic pre- and postconditioning in rat hearts. Hearts isolated from male Wistar rats were subjected to 1) time-matched nonischemic perfusion, 2) ischemia-reperfusion (30 min of coronary occlusion and 120 min of reperfusion), 3) preconditioning (3 × 5 min of coronary occlusion) followed by ischemia-repe...

Advancements in Case Studies Quantum microRNA Assessment of COVID-19 RNA Vaccine: Hidden Potency BNT162b2 SASR-CoV-2 Spike as MicroRNA Vaccine Fujii YR* Kawada-Cho, 106-6, Atsuta-Ku, Nagoya, Japan *Corresponding author: Yoichi Robertus Fujii, Submission: March 05, 2021;Published: 16, 2021 DOI: 10.31031/AICS.2021.03.000552 ISSN 2639-0531Volume3 Issue1

bladder cancer is the fifth most common cancer with significant morbidity and mortality. recently, numerous studies demonstrated that micrornas are emerging as diagnostic biomarkers for bladder cancer. specific mirna profiles have been identified for several samples from patients with bladder cancer. micrornas are noncoding rna molecules of approximately 23 nucleotides that play important roles...

objective(s): menopause and diabetes obviously increase the risk of cardiovascular disease in women. the aims of the present study were to evaluate the effects of ovariectomy in type 2 diabetes on the histology and expression of mirna-29, mirna-133, igf-1 and bcl-2 genes and bcl-2 protein and caspase 3 activity in the hearts of female rats. materials and methods: forty female wistar rats were d...

results treatments through mirnas can prove to be beneficial due to its small size, easy synthesis, targeted and quick delivery. conclusions further work is needed to be done to make mirna treatments available to large number of people suffering from various bone diseases. context mirnas can regulate the expression of genes by interfering in their mrnas, acting as key regulators of diverse cell...

Although myocardial ischemia-reperfusion injury (I/R) and its pathological consequences are the leading cause of morbidity mortality worldwide, cardioprotective therapeutics still not on market. Oxidative stress, a major contributing factor to I/R, changes transcription coding non-coding RNAs, alters post-transcriptional modulations, regulate protein function. MicroRNA (miRNA) expression can be...

objective(s):micrornas (mirnas) are small non-coding rna molecules that regulate gene expression. they have important roles in kidney development, homeostasis and disease, and participate in the onset and progression of tubulointerstitial sclerosis and end-stage glomerular lesions that occur in various forms of chronic kidney disease (ckd). in the present study, we elucidated the role of micror...