single-nucleotide polymorphisms (snps) in mirnasmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. our study aimed to evaluate the possible association between mirna-146a rs2910164 and mirna-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (ptb) in a sample of iranian population. this case- control study was perfor...

Abstract Background Autism spectrum disorder is a condition related to brain development that affects person’s perception and socialization, resulting in problems social interaction communication. It has no single known cause, yet several different genes appear be involved autism. As genetically complex disease, dysregulation of miRNA expression miRNA–mRNA interactions might feature autism diso...

Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was perfor...

MicroRNA (miRNA) has emerged as a promising alternative therapeutic treatment for cancer, but its delivery been hindered by low cellular uptake and degradation during circulation. In this review, we discuss the various methods of delivering miRNA, including viral non-viral systems such liposomes nanoparticles. We also examine use nanoparticles miRNA-based diagnostics. focus specifically on util...

Phase-separated biomolecular droplets are formed in cells to regulate various biological processes. This phenomenon can be applied constructing self-assembled dynamic molecular systems such as artificial and robots. Recently, programmable phase-separated called DNA have been reported a possible method construct systems. study reports computational droplet that recognize specific combination of ...

The excess of unbound α globin chains are the basic pathophysiology cause clinical symptoms in major β thalassemia. Recently there many alternative therapies by increasing γ to reduced effects chains. Alternative decreasing have not been much noticed. expression involves complex regulatory involving transcription factors and miRNAs. It GATA-1, KLFD MYB . also miRNA-144 miRNA-150. role miRNA-150...

Introduction This study aimed to evaluate the TRE-induced changes in serum expression levels of miRNAs associated with lipids metabolism and autophagy process MI patients assess potential protective effects TRE these patients. Material methods post hoc investigation was performed on samples obtained from a pilot randomized, double blind, placebo-controlled clinical trial that recruited 14 men (...