نتایج جستجو برای: mito mycin c

تعداد نتایج: 1059857  

Journal: :Haematologica 2013
Damia Romero-Moya Clara Bueno Rosa Montes Oscar Navarro-Montero Francisco J Iborra Luis Carlos López Miguel Martin Pablo Menendez

The homeostasis of the hematopoietic stem/progenitor cell pool relies on a fine-tuned balance between self-renewal, differentiation and proliferation. Recent studies have proposed that mitochondria regulate these processes. Although recent work has contributed to understanding the role of mitochondria during stem cell differentiation, it remains unclear whether the mitochondrial content/functio...

2008
Kazuto NAKADA Akitsugu SATO Jun-Ichi HAYASHI

In the situation that it would not be able to produce model animals for mitochondrial diseases caused by mitochondrial DNA (mtDNA) with pathogenic mutations, we succeeded in generating mice with pathogenic deletion mutant mtDNA (DeltamtDNA), named "mito-mice", by direct introduction of mitochondria with DeltamtDNA into mouse zygotes. In the mito-mice, accumulation of DeltamtDNA induced mitochon...

Journal: :Free radical biology & medicine 2009
Jacek Zielonka Micael Hardy B Kalyanaraman

Methods for the detection and quantitation of hydroethidine (HE) and its oxidation products by HPLC analysis are described. Synthetic methods for preparation of authentic standards (2-hydroxyethidium and diethidium) are provided. Potential applications of the HPLC methods to chemical and biological systems are discussed. Specific examples of chromatograms obtained using UV-Vis absorption, fluor...

2012
C. Floss T. Noguchi

OTHER PRIMITIVE EXTRATERRESTRIAL MATERIALS. C. Floss, T. Noguchi, and T. Yada. Laboratory for Space Sciences and Physics Department, Washington University, St. Louis, MO 63130, USA. Dept. of Materialogical and Biological Science, Ibaraki University, Mito, Ibaraki 310-8512, Japan. Japan Aerospace Exploration Agency, Institute of Space and Astronautical Science, Sagamihara, Kanagawa 252-5210, Jap...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Kristine M Robinson Michael S Janes Mariana Pehar Jeffrey S Monette Meredith F Ross Tory M Hagen Michael P Murphy Joseph S Beckman

The putative oxidation of hydroethidine (HE) has become a widely used fluorescent assay for the detection of superoxide in cultured cells. By covalently joining HE to a hexyl triphenylphosphonium cation (Mito-HE), the HE moiety can be targeted to mitochondria. However, the specificity of HE and Mito-HE for superoxide in vivo is limited by autooxidation as well as by nonsuperoxide-dependent cell...

Journal: :The American journal of physiology 1999
Salvatore Pepe Naotaka Tsuchiya Edward G Lakatta Richard G Hansford

Aberrations in cell Ca2+ homeostasis have been known to parallel both changes in membrane lipid composition and aging. Previous work has shown that the lowered efficiency of work performance, which occurs in isolated hearts from rats fed a diet rich in n-6 polyunsaturated fatty acids (PUFA), relative to those fed n-3 PUFA, could be raised by mitochondrial (Mito) Ca2+ transport inhibition. We te...

Journal: :Journal of the American Chemical Society 2015
Hyo Sung Jung Jiyou Han Jae-Hong Lee Ji Ha Lee Jong-Min Choi Hee-Seok Kweon Ji Hye Han Jong-Hoon Kim Kyung Min Byun Jong Hwa Jung Chulhun Kang Jong Seung Kim

Mitochondria are organelles that are readily susceptible to temperature elevation. We selectively delivered a coumarin-based fluorescent iron oxide nanoparticle, Mito-CIO, to the mitochondria. Upon 740 nm laser irradiation, the intracellular temperature of HeLa cells was elevated by 2.1 °C within 5 min when using Mito-CIO, and the treatment resulted in better hyperthermia and a more elevated cy...

Journal: :Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2014
Pushpa Raj Joshi Mirjam Vetterke Anja Hauburger Pawel Tacik Gisela Stoltenburg Frank Hanisch

Cytochrome c oxidase (COX)-deficient fibers and multiple mitochondrial DNA (mtDNA) deletions are frequent findings in sporadic inclusion body myositis (s-IBM). However, the functional impact of these defects is not known. We investigated oxygen desaturation during exercise using the forearm exercise test, accumulation of lactate during exercise using a cycle ergometry test and mitochondrial cha...

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