The nearby BL Lacertae (BL Lac) object Markarian 421 (Mkn 421) at a red shift z = 0.031 was observed to undergo strong TeV γ-ray outbursts in the observational periods from December 1999 until May 2001. The time averaged flux level F (E > 1TeV) in the 1999/2000 season was (1.43± 0.04) ·10−11 ph cm−2 s−1, whereas in the 2000/2001 season the average integral flux increased to (4.19±0.04) ·10−11 p...

INTRODUCTION The potential of a radioiodine-labeled, anti-adenosine triphosphate synthase monoclonal antibody (ATPS mAb) as a theragnostic agent for simultaneous cancer imaging and treatment was evaluated. METHODS Adenosine triphosphate synthase monoclonal antibody was labeled with radioiodine, then radiotracer uptake was measured in 6 different cancer cell lines. In vivo biodistribution was ...

PURPOSE Epidemiological, clinical, and laboratory studies have suggested that ibuprofen, a commonly used nonsteroidal anti-inflammatory drug, inhibits the promotion and proliferation of certain tumors. Recently, we demonstrated the antiproliferative effects of ibuprofen on the human gastric cancer cell line MKN-45. However, high doses of ibuprofen were required to elicit these antiproliferative...

metformin has recently been introduced as an anti-cancer agent. in this study, we evaluated the effect of metformin and metformin/cisplatin on human gastric mkn-45 cell line. when we used metformin alone, it could inhibit proliferation and induce apoptosis, but it diminish anti-proliferative effects of cisplatin when they are used in combination. further, we checked mrna levels of survivin, mto...

We use the new results of the HEGRA detector on the TeV γ–ray emission from MKN 501 to set upper limits on the energy density of the cosmic infrared background (CIRB). Contrary to previous interpretations of the γ–ray spectrum of MKN 421 as showing an intergalactic absorption cutoff at 5 TeV, the observed spectrum of MKN 501 extends beyond 10 TeV and appears to be unattenuated by γγ collisions ...

BACKGROUND This study aims to investigate the effect of miR-10b overexpression on cancer cell proliferation, migration, invasion, and Hoxd10 expression. METHODS The effect of miR-10b on proliferation, migration, and invasion of MKN-28, BGC-823, and SGC-7901 cells and the expression of Hoxd10 protein in SGC-7901 and BGC-823 cells were detected following transfection of miR-10b inhibitor or Neg...

Gastric cancer is the most common cancer in Eastern Asia. Increasing chemoresistance and general systemic toxicities have complicated the current chemotherapy leading to an urgent need of more effective agents. The present study reported a potent DNA topoisomerase IIα inhibitory activity of an andrographolide analogue (19-triisopropyl andrographolide, analogue-6) in gastric cancer cells; MKN-45...

BACKGROUND Radix astragali mainly contains saponins, polysaccharides, flavonoids, amino acids and other chemical constituents of which total astragalosides have immunomodulatory, anti-viral, hepatoprotective, and gastric mucosa protective effects. OBJECTIVE To investigate the process conditions for extraction, purification and enrichment of total astragalosides by macroporous adsorption resin...

The cancer stem cell theory hypothesizes that cancer stem cells (CSCs), which possess self-renewal and other stem cell properties, are regarded as the cause of tumor formation, recurrence and metastasis. The isolation and identification of CSCs could help to develop novel therapeutic strategies specifically targeting CSCs. In this study, we enrich...