OBJECTIVE Low-income and minority adolescents are at high risk for poor asthma outcomes, due in part to adherence. We tested acceptability, feasibility, and effect sizes of an adherence intervention for low socioeconomic status (SES) minority youth with moderate- and severe-persistent asthma. Design and Methods Single-site randomized pilot trial: intervention (n = 12; asthma education, motivati...

Asthma studies suggest that alteration in the inflammation pattern may be associated with the severity of asthma. The aim of this study was to compare in vitro the expression of chemokines, chemokine receptors and cytokine production from CD4+ T human lymphocytes of asthmatic, both obese and non-obese patients with different severity levels of asthma. Lymphocytes were labeled with monoclonal an...

Method Children with asthma who were followed in our outpatient department of pediatric allergy unit were consecutively recruited. Asthma severity was graded according to NAEPP guidelines. Patients were categorized into two groups; children with intermittent and mild persistent asthma formed Group 1 (mild asthma) whereas children with moderate and severe persistent asthma formed Group 2 (severe...

BACKGROUND The aim of this study was to explore whether serum baseline tryptase (sBT) levels might be a useful marker not only for the accurate diagnosis of childhood asthma, but also for the prediction of disease severity. METHODS A total of 114 asthmatic children were enrolled in this study, 36 of whom had mild intermittent asthma, 38 had mild persistent asthma, and 40 had moderate to sever...

OBJECTIVE To determine whether secondhand smoke (SHS) exposure is associated with greater asthma severity in children with physician-diagnosed asthma living in CT, and to examine whether area of residence, race/ethnicity or poverty moderate the association. METHODS A large childhood asthma database in CT (Easy Breathing) was linked by participant zip code to census data to classify participan...

Background: Adenosine deaminase (ADA) and 5ʹ-nucleotidase (5ʹ-NT) play a crucial role in adenosine metabolism in healthy individuals. Adenosine is an inflammatory mediator of asthma. Changes in adenosine metabolism and role of ADA and 5ʹ-NT in regulating adenosine level in asthmatics and correlation of these changes with severity of asthma are not clearly understood. Methods: In this study, we ...

BACKGROUND Difficult-to-control asthma has been associated with gastroesophageal acid reflux. Acid-suppressive treatment has been inconsistent in improving asthma control. OBJECTIVE To determine whether a proton-pump inhibitor improves asthma control in adult asthmatic patients with acid reflux symptoms. DESIGN Multicenter, double-blind, randomized, placebo-controlled trial. SETTING Twent...

the prevalence of both obesity and asthma has increased in recent years. thus we decided to investigate the relation between obesity and asthma severity. we undertook a cross-sectional study in outpatient asthma clinics of 2 tertiary hospitals in tehran. obesity was defined as a body mass index greater than 30. asthma severity was defined by using the guide for asthma management and prevention ...

The severity of asthma can be graded from mild intermittent to severe persistent. Airway inflammation is a feature of persistent asthma. We compared several markers of inflammation in mucosal biopsies and bronchoalveolar lavage fluid (BAL fluid) from 12 healthy control subjects, 24 patients with intermittent asthma, and 18 patients with mild-to-moderate persistent asthma. Epithelial shedding, e...