although current guidelines place single leukotriene receptor antagonists use as a therapeutic option in mild persistent asthma, there is still uncertainty about its place. in this study efficiency of montelukast monotherapy in children with moderate persistent asthma was evaluated. children (age 6 to 16) with persistent moderate asthma were treated prospectively with budesonide combined with m...

background and purpose: the goal of asthma therapy is to achieve clinical control and near normal lung functions. many patients with moderate persistent asthma fail to achieve this goal with a low dose of inhaled corticosteroid (ïçs) plus long-acting β2 agonist (lâbâ). ïn the present study, we have checked whether another controller medication (in the form of ginger capsule) add on to ïçslow do...

Background and Objective: Asthma is the most common chronic disease of childhood. The disease is caused by a temporary blockage of airflow due to chronic inflammation of the airways . One of the conditions that often occur with asthma and exacerbate disease, is gastroesophageal reflux. The aim of this study is to evaluate the role of acid suppressing therapy in patients with refractory asthma...

the aim of this study was to demonstrate that handgrip strength test can discriminate the presence/absence of asthma and between intermittent and moderate persistent asthma in children. 140 children (70 healthy and 70 with asthma) completed the pediatric asthma quality of life questionnaire (paqlq) and performed the handgrip strength test. forty-eight hours later, subjects performed spirometry....

background and objective: asthma is the most common chronic disease of childhood. the disease is caused by a temporary blockage of airflow due to chronic inflammation of the airways . one of the conditions that often occur with asthma and exacerbate disease, is gastroesophageal reflux. the aim of this study is to evaluate the role of acid suppressing therapy in patients with refractory asthma. ...

  Background Endothelial Cell-Specific Molecule-1 (ESM-1) is a 50 kDa soluble proteoglycan that is produced mainly the vascular endothelial cells of the kidney and lung. It is produced by the effects of proangiogenic and pro-inflammatory cytokines, and it indicates activation and dysfunction of the vascular endothelium. We aimed to detect the role of ESM-1 in childre...

Th17 cells and IL-17A play a role in the development and progression of allergic diseases. We analyzed the IL-17A levels in sputum supernatants (Ss), nasal wash (NW) and plasma (P) from Healthy Controls (HC) and children with Asthma/Rhinitis. We tested the expression of IL-17A, RORγ(t) and FOXP3 in peripheral blood T-lymphocytes from intermittent and mild-moderate asthma. The effect of Budesoni...

Twenty-four patients of moderate persistent perennial asthma with documented aggravation to severe persistent asthma, during monsoon season in the past two years, were put on specific elimination diet during August and September. The diet was based on results of in-vitro allergy tests for a selected food panel. On specific elimination diet, five patients improved to mild persistent asthma and t...

Background: IL-17 is a major cytokine player in T cell mediated leukocyte associated inflammation. IL-17 is also recognized to participate in the pathophysiology of asthma. Objective: To determine the role of IL-17 in predicting severe asthma. Methods: We obtained serum samples from asthmatic children under the age of 5-year in three different groups of mild (n=33), moderate (n=28) and severe (...