We have developed a family of quantitative descriptors in order to provide noninvasive, reliable means of distinguishing benign from malignant breast lesions. These include acoustic descriptors (“echogenicity,” “heterogeneity,” “shadowing”) and morphometric descriptors (“area,” “aspect ratio,” “border irregularity,” “margin definition”). These quantitative descriptors are designed to be indepen...

Ethanol has chronobiological effects, which are associated with inhibition of melatonin synthesis and secretion disruption the sleep-wake cycle. is known to cause sleep fragmentation due frequent awakenings, prolong wakefulness, reduce duration slow phase. At same time, changes in morphology pineal gland under chronic exposure ethanol remain poorly studied. Of particular interest basic morphome...

PURPOSE To quantify the distribution and morphometric characteristics of capillary networks in the human perifovea. To determine correlations between the location of neuronal subcellular compartments and the morphometric features of regional capillary networks in the layered retina. METHODS The perifoveal region, located 2 mm nasal to the fovea, was studied in 17 human donor eyes. Novel micro...

Objective: The differentiation of atypical complex type endometrial hyperplasia (ACEH) and low grade endometrial carcinoma (EC) may be problematic in endometrial biopsy materials. Desmoplasia and stromal invasion are diagnostic for EC but they are not always demonstrated in endometrial biopsies. In this study, we investigated the contribution of nuclear morphometry to distinction of ACEH and lo...

OBJECTIVES Transformation of normal epithelium into cancer cells involves epigenetic and genetic changes and modifications in nuclear structure and tissue architecture. To evaluate nuclear morphometric alterations and clinicopathologic features for organ- vs nonorgan-confined prostate carcinoma (PCa) prediction. METHODS Of 557 prospectively enrolled patients, 370 had complete information and ...

Morphometric approaches can be combined with 2D or 3D imaging to quantitatively evaluate craniofacial medical conditions depicted in material culture and to learn more about the culture being studied. A terra-cotta figurine (circa 500 A.D.) from the Tolteca culture of Mexico has previously been qualitatively “diagnosed” with Down syndrome (DS) based on the presence or absence of facial features...

Interneuron classification is an important and long-debated topic in neuroscience. A recent study provided a data set of digitally reconstructed interneurons classified by 42 leading neuroscientists according to a pragmatic classification scheme composed of five categorical variables, namely, of the interneuron type and four features of axonal morphology. From this data set we now learned a mod...