Sepsis is the most common cause of death in critically ill patients and it may be associated with multiorgan failure, including acute kidney injury (AKI). This situation can require acute renal support and increase mortality. Therefore, it is essential to administrate antimicrobials in dosis to achieve adequate serum levels, preventing overdosis and drug toxicity or underdosing and risk for res...

GASTROINTESTINAL ENDOSCOPY S231 Caused primarily by gallstones and alcohol in the adult U.S. population, acute pancreatitis is associated with considerable morbidity. Mortality rates, in turn, have been reported as between 5% and 10% and usually are the consequence of sepsis or multiorgan failure.1-4 ERCP interaction in acute pancreatitis has primarily been one of cause and effect.5 In other wo...

Zinc Phosphide(Zn3P2) is a common rodenticide freely available in Nigeria for use against rodents. Occasionally human consumption occurs either accidentally or intentionally with potential consequences of multiorgan toxicity and death. An 11-year-old boy consumed an unknown quantity zinc phosphide marketed as Push Out® the intention committing suicide killing some members family his response to...

The systemic amyloidoses comprise an increasing number of diseases characterized by multiorgan deposition of misfolded and aggregated autologous proteins as b-pleated sheet fibrils. Immunoglobulin light chain (AL) amyloidosis is the most common (incidence ;10 patients per million per year) and the most severe because it often targets the heart. A small, usually indolent plasma cell (PC) clone s...

About 95% of ethanol is metabolised via the oxidative pathway. Trace amounts of ethanol are a substrate of non-oxidative metabolism, which generates such products as fatty acid ethyl esters, phosphatidylethanol and ethyl glucuronide. Ethanol also changes the metabolic pathway of serotonin (5-hydroxytryptophol) and transferrin. Multiorgan toxicity of these metabolites increases our understanding...

UNLABELLED A 36-year-old female was hospitalized with symptoms suggesting intestinal occlusion. She was diagnosed with adenocarcinoma of the ampulla of Vater (pT4N0 stage) and underwent cephalic duodenopancreatectomy 8 months ago. Five cycles of postoperative chemotherapy were administrated using capecitabine and oxaliplatin (CAPOX or XELOX), the last one being completed 1 month ago. During the...

Accumulating studies in animals have shown that nanoparticles could cause unusual rapid lung injury and extrapulmonary toxicity. Whether exposure of workers to nanoparticles may result in some unexpected damage as seen in animals is still a big concern. We previously reported findings regarding a group of patients exposed to nanoparticles and presenting with an unusual disease. The reported dis...

Several research papers published in Critical Care throughout 2007 examined the pathogenesis, diagnosis, treatment and prognosis of sepsis and multiorgan failure. The present review summarizes the findings and implications of the papers published on sepsis and multiorgan failure and places the research in the context of other work in the field.

Advances in treatment, risk stratification, and supportive care have improved survival of patients with cancer over the last two decades (1). AKI may result from the cancer itself (e.g., infiltration or obstruction), the treatment of cancer (e.g., chemotherapy toxicity), or associated complications (e.g., sepsis). Cancer, by itself, is not a contraindication for starting RRT, even in the settin...