BACKGROUND Cognitive dysfunction affects up to 65% of multiple sclerosis (MS) patients and progresses over time. Natalizumab has been shown to be superior to placebo in preserving cognition for the first two years of therapy. OBJECTIVES The objectives of this study are to understand the impact of natalizumab on cognition beyond two years of therapy and to investigate whether baseline characte...

When nonmetastatic dimethylbenzanthracene-induced rat mammary cancer cells (RMC1) were transfected with a control plasmid containing the neomycin resistance gene (i.e., Neo/Only), none of the five clonal Neo/Only transfectants isolated and characterized was metastatic, only one of five had a single structural chromosomal abnormality, and only one of five had a single numerical chromosomal chang...

introduction: most of the hematologic malignancies are heterogenous with regard to morphology, immunophenotype, and genetic rearrangements. multiple recurrent chromosomal aberrations have been identified by conventional cytogenetic analysis, which is now widely recognized as one of the most important diagnostic and prognostic determinants in these patients. patients and methods: bone marrow sam...

When nonmetastatic dimethylbenzanthracene-induced rat mammary cancer cells (KM( I ) were transfected with a control plasmili containing the neomycin resistance gene (i.e.. Neo/Only), none of the five clonal Neo/Only transfectants isolated and characterized was metastatic, only one of five had a single structural chromosomal abnormality, and only one of five had a single numerical chromosomal ch...

Cancers are complex diseases, characterized by genomic changes at multiple levels of regulation. We present an integrative genome-wide approach that captures shared patterns from several data sources and extracts chromosomal regions predictive of patient survival in glioblastoma multiforme (GBM) progression and drug resistance. Our results identify known and novel genomic regions that may contr...

Both the incidence of invasive fungal infections and rates of multidrug resistance associated with fungal pathogen Candida glabrata have increased in recent years. In this perspective, we will discuss the mechanisms underlying the capacity of C. glabrata to rapidly develop resistance to multiple drug classes, including triazoles and echinocandins. We will focus on the extensive genetic diversit...

Reproductive isolation in plants occurs through multiple barriers that restrict gene flow between populations, but their origins remain uncertain. Work in the past decade has shown that postpollination barriers, such as the failure to form hybrid seeds or sterility of hybrid offspring, are often less strong than prepollination barriers. Evidence implicates multiple evolutionary forces in the or...

Chromosomal translocations are a hallmark of lymphoid tumours. Multiple myeloma (MM) is a tumour of the plasma cell, the terminally differentiated B lymphoid cell. In recent years, a large number of chromosomal and genetic abnormalities have been detected in myeloma, the most prominent being chromosome 13q deletions and translocations affecting the immunoglobulin heavy chain (IgH) locus on chro...

Joint replacement has alleviated the suffering of millions of patients who would otherwise be crippled by arthritis. Whatever the uncertainties about the effects of this procedure , the benefits are very real. This is of paramount importance when evaluating any risks from surgery. Uncertainties arise because all foreign materials produce a tissue reaction when they are implanted in the body. Th...