SETTING Nationwide Canadian public health surveillance. OBJECTIVE Description of demographic features and disease characteristics of drug-resistant tuberculosis (TB) in Canada over a 12 year period. DESIGN Continuous surveillance of all cases of culture-confirmed TB in Canada. Demographic and microbiologic features were analyzed and comparisons between drug-susceptible, multidrug-resistant ...

Although, generally speaking, haematological malignancies are chemotherapy-responsive tumours and high remission induction rates are obtained, disease-related death is the rule rather than the exception. The appearance of cell populations, resistant to multidrug-based chemotherapy, constitutes the major problem to achieve cures in these patients. Advances in cell biology have partly contributed...

Objective: Almost all year round occurrence of typhoid fever remains a major public health issue in Bangladesh. In recent years, there has been significant rise the prevalence multi-drug resistance Salmonella typhi Dhaka city. The objective this study was to observe and Extended drug-resistant patterns typhoidal among patients attending tertiary medical center by conventional culture serologic ...

the emergence of multi-drug resistant strains of pseudomonas aeruginosa has complicated treatment decision and may lead to treatment failures. in this study, we describe the trends of drug-resistant p. aeruginosa isolated in blood cultures from patients detected in a tertiary teaching hospital and evaluated the prevalence of resistance to amikacin, ampicillin, carbeni- cillin, cefixime, cefotax...

Pseudomonas aeruginosa (P. aeruginosa) bacteremia causes significant mortality rate due to emergence of multidrug resistant (MDR) nosocomial infections. We report the draft genome sequence of P. aeruginosa strain VRFPA09, a human bloodstream isolate, phenotypically proven as MDR strain. Whole genome sequencing on VRFPA09, deciphered betalactamase encoding blav(eb-1) and bla(OXA-10) genes and mu...

Three independent variants (G2, G4, G5), resistant to methylglyoxal bis(guanylhydrazone), an anticancer drug, have been isolated by single step selection from an adenovirus-transformed rat brain cell line (1). These variants display selective cross-resistance to several natural product drugs of dissimilar structure and action. Multidrug resistance has recently been shown to be caused by overexp...

Background: Drug-Resistant Tuberculosis (DR-TB) is one of the major public health issues globally. Zambia highly burdened by TB and multi-drug resistant TB. In this study, sputum samples obtained from new previously treated cases were examined for drug-resistant Mycobacterium tuberculosis (MTB). Methods: Sputum specimens processed using N-acetyl-L-cysteine-sodium hydroxide method, stained fluor...

530 0968 – 0004/00/$ – See front matter © 2000, Elsevier Science Ltd. All rights reserved. PII: S0968-0004(00)01668-6 SYSTEMIC CHEMOTHERAPY WITH cytotoxic drugs is a widely used treatment that improves long-term survival of cancer patients. Yet, it has been estimated that only ~10% of chemotherapy-treated patients are ultimately cured1. The main reason for the limited efficacy of chemotherapy i...

Herein, we identify vceC as a component of a vceCAB operon, which codes for the Vibrio cholerae VceAB multiple-drug resistance (MDR) efflux pump, and vceR, which codes for a transcriptional autoregulatory protein that negatively regulates the expression of the vceCAB operon and is modulated by some of the substrates of this MDR efflux pump.