By D. L. DUNGwORTH, NI. GOLDMAN, J. W. SWITZER AND D. H. MCKELVIE T HE TERM “MYELOPROLIFERATIVE DISORDER” was introduced by 2 to embrace a complex array of diseases characterized by irreversible proliferation of one to several of the bone marrow cell lines, and includes such conditions as granulocytic leukemia, myelofibrosis with myeloid metaplasia, polycythemia vera and erythremic myelosis. Th...

BACKGROUND A number of studies showed that the JAK2 V617F mutation increases the thrombotic risk in patients with myeloproliferative disorders (MPN) while others did not reveal this correlation, and it is unknown whether inherited thrombophilia is an additive risk factor in mutated subjects. Our aim was to clarify the contribution of JAK2 V617F to a hypercoagulable state, as well as its interac...

Gelatinous bone marrow transformation (GMT) is a rare disorder characterized by the presence of fat cell atrophy, loss of hematopoietic cells, and deposition of extracellular gelatinous materials. GMT is not a specific disease, but is strongly associated with malnutrition and drugs. Albeit extremely rare, GMT has been reported in patients with myeloproliferative disorders. Herein, we report the...

1. Jones AV, Kreil S, Zoi K, et al. Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood. 2005;160:2162-2168. 2. Levine RL, Wadleigh M, Cools J, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005;7:387-397. 3. Zhao R, Xing S, Li Z, et al. I...

The pathogenesis of myeloproliferative disorder remains unknown, but there have been some experiments on murine myeloproliferative sarcoma induced by certain viruses. Myeloproliferative sarcoma virus which is well known among such viruses, causes myeloproliferative disorder in mice and today's work will reveal tumorigenicity of this virus in rats. Two groups of Jar-2 rats (31 young rats and 28 ...

Extramedullary hematopoiesis is a complication of a number of myeloproliferative disorders. MR imaging of the orbits was performed in a patient with bilateral orbital swelling with known myeloproliferative disorder and myelofibrosis. The study revealed symmetric, bilateral enhancing masses in the lacrimal fossae extending into the nasolacrimal ducts. Biopsy demonstrated sclerotic extramedullary...